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Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers

Kim, In-Jung and Zhang, Yifeng and Meister, Markus and Sanes, Joshua R. (2010) Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers. Journal of Neuroscience, 30 (4). pp. 1452-1462. ISSN 0270-6474. PMCID PMC2822471. http://resolver.caltech.edu/CaltechAUTHORS:20170405-065327156

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Abstract

Retinal ganglion cells (RGCs), which transfer information from the eye to the brain, are heterogeneous in structure and function, but developmental studies have generally treated them as a single group. Here, we investigate the development of RGC axonal and dendritic arbors using four mouse transgenic lines in which nonoverlapping subsets of RGCs are indelibly labeled with a fluorescent protein. Each subset has a distinct functional signature, size, and morphology. Dendrites of each subset are restricted to specific sublaminae within the inner plexiform layer in adulthood, but acquire their restriction in different ways: one subset has lamina-restricted dendrites from an early postnatal stage, a second remodels an initially diffuse pattern, and two others develop stepwise. Axons of each subset arborize in discrete laminar zones within the lateral geniculate nucleus or superior colliculus, demonstrating previously unrecognized subdivisions of retinorecipient layers. As is the case for dendrites, lamina-restricted axonal projections of RGC subsets develop in different ways. For example, while axons of two RGC subsets arborize in definite zones of the superior colliculus from an early postnatal stage, axons of another subset initially occupy a deep layer, then translocate to a narrow subpial zone. Together, these results show that RGC subsets use a variety of strategies to construct lamina-restricted dendritic and axonal arbors. Taking account of these subtype-specific features will facilitate identification of the molecules and cells that regulate arbor formation.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1523/JNEUROSCI.4779-09.2010DOIArticle
http://www.jneurosci.org/content/30/4/1452.longPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822471/PubMed CentralArticle
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2010 the authors.Beginning six months after publication the Work will be made freely available to the public on SfN’s website to copy, distribute, or display under a Creative Commons Attribution 4.0 International (CC BY 4.0) license (https://creativecommons.org/licenses/by/4.0/). Received Sept. 25, 2009; revised Dec. 1, 2009; accepted Dec. 5, 2009. This study was supported by grants from National Institutes of Health to M.M., J.R.S., and I.-J.K., a Bushrod H. Campbell and Adah F. Hall Charity Fund Fellowship to I.-J.K, a Damon Runyon Fellowship to Y.Z., and a Merck Award for Genome-Related Research to I.-J.K. We thank Renate Hellmiss, Debbie Pelusi, Sara Haddad, and Laura Stoppel for advice and assistance.
Funders:
Funding AgencyGrant Number
NIHUNSPECIFIED
Bushrod H. Campbell and Adah F. Hall Charity FundUNSPECIFIED
Damon Runyon Cancer Research FoundationUNSPECIFIED
MerckUNSPECIFIED
PubMed Central ID:PMC2822471
Record Number:CaltechAUTHORS:20170405-065327156
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170405-065327156
Official Citation:Laminar Restriction of Retinal Ganglion Cell Dendrites and Axons: Subtype-Specific Developmental Patterns Revealed with Transgenic Markers In-Jung Kim, Yifeng Zhang, Markus Meister, Joshua R. Sanes Journal of Neuroscience 27 January 2010, 30 (4) 1452-1462; DOI: 10.1523/JNEUROSCI.4779-09.2010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75713
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Apr 2017 16:14
Last Modified:05 Apr 2017 16:14

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