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Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2

Stowers, Lisa and Holy, Timothy E. and Meister, Markus and Dulac, Catherine and Koentges, Georgy (2002) Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2. Science, 295 (5559). pp. 1493-1500. ISSN 0036-8075. doi:10.1126/science.1069259. https://resolver.caltech.edu/CaltechAUTHORS:20170405-070334559

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Abstract

The mouse vomeronasal organ (VNO) is thought to mediate social behaviors and neuroendocrine changes elicited by pheromonal cues. The molecular mechanisms underlying the sensory response to pheromones and the behavioral repertoire induced through the VNO are not fully characterized. Using the tools of mouse genetics and multielectrode recording, we demonstrate that the sensory activation of VNO neurons requires TRP2, a putative ion channel of the transient receptor potential family that is expressed exclusively in these neurons. Moreover, we show that male mice deficient in TRP2 expression fail to display male-male aggression, and they initiate sexual and courtship behaviors toward both males and females. Our study suggests that, in the mouse, sensory activation of the VNO is essential for sex discrimination of conspecifics and thus ensures gender-specific behavior.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://dx.doi.org/10.1126/science.1069259DOIArticle
http://science.sciencemag.org/content/295/5559/1493.longPublisherArticle
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2002 American Association for the Advancement of Science. 12 September 2001; accepted 16 January 2002. Published online 31 January 2002. We thank M. A. Wilson for experimental advice; R. Hellmiss-Peralta for the illustration; T. C. Lee for help with the manuscript preparation; P. Jiang, J. Dubauskaite, and M. E. Klein for help with gene targeting; and D. Haig and members of the Dulac and Meister labs for helpful comments. Financially supported by the Howard Hughes Medical Institute (L.S.); NIH grant DC03903 (C.D.); and Office of Naval Research grant (M.M.), Human Frontier Science Program (G.K.), and Jane Coffin Childs Memorial Fund (T.E.H.) fellowships.
Funders:
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
NIHDC03903
Office of Naval Research (ONR)UNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
Issue or Number:5559
DOI:10.1126/science.1069259
Record Number:CaltechAUTHORS:20170405-070334559
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170405-070334559
Official Citation:Loss of Sex Discrimination and Male-Male Aggression in Mice Deficient for TRP2 BY LISA STOWERS, TIMOTHY E. HOLY, MARKUS MEISTER, CATHERINE DULAC, GEORGY KOENTGES SCIENCE 22 FEB 2002 : 1493-1500
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75714
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Apr 2017 16:12
Last Modified:15 Nov 2021 16:35

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