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Dynamical Adaptation in Photoreceptors

Clark, Damon A. and Benichou, Raphael and Meister, Markus and da Silveira, Rava Azeredo (2013) Dynamical Adaptation in Photoreceptors. PLOS Computational Biology, 9 (11). Art. No. e1003289. ISSN 1553-7358. PMCID PMC3828139. doi:10.1371/journal.pcbi.1003289. https://resolver.caltech.edu/CaltechAUTHORS:20170405-092056680

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Abstract

Adaptation is at the heart of sensation and nowhere is it more salient than in early visual processing. Light adaptation in photoreceptors is doubly dynamical: it depends upon the temporal structure of the input and it affects the temporal structure of the response. We introduce a non-linear dynamical adaptation model of photoreceptors. It is simple enough that it can be solved exactly and simulated with ease; analytical and numerical approaches combined provide both intuition on the behavior of dynamical adaptation and quantitative results to be compared with data. Yet the model is rich enough to capture intricate phenomenology. First, we show that it reproduces the known phenomenology of light response and short-term adaptation. Second, we present new recordings and demonstrate that the model reproduces cone response with great precision. Third, we derive a number of predictions on the response of photoreceptors to sophisticated stimuli such as periodic inputs, various forms of flickering inputs, and natural inputs. In particular, we demonstrate that photoreceptors undergo rapid adaptation of response gain and time scale, over ∼ 300 ms—i. e., over the time scale of the response itself—and we confirm this prediction with data. For natural inputs, this fast adaptation can modulate the response gain more than tenfold and is hence physiologically relevant.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1371/journal.pcbi.1003289DOIArticle
http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003289PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828139PubMed CentralArticle
ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2013 Clark et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Received May 20, 2011; Accepted September 3, 2013; Published November 14, 2013. We acknowledge Stephen Baccus, Michael J. Berry II, Tom Clandinin, Vincent Hakim, and Simon Laughlin for helpful discussions and comments on the manuscript. We thank Stephen Baccus for the salamander cone cell recordings. Author Contributions: Conceived and designed the experiments: DAC MM RAdS. Analyzed the data: DAC RB MM RAdS. Wrote the paper: DAC MM RAdS. This work was supported by the Jane Coffin Childs Fund and a CNRS postdoctoral fellowship (DAC), the Ecole Polytechnique (RB), a grant from the NIH (MM), and the CNRS though UMR 8550, the Université Pierre et Marie Curie, and the Université Denis Diderot (RAdS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have declared that no competing interests exist.
Funders:
Funding AgencyGrant Number
Jane Coffin Childs Memorial Fund for Medical ResearchUNSPECIFIED
Centre National de la Recherche Scientifique (CNRS)UMR 8550
Ecole PolytechniqueUNSPECIFIED
NIHUNSPECIFIED
Université Pierre et Marie CurieUNSPECIFIED
Université Denis DiderotUNSPECIFIED
Issue or Number:11
PubMed Central ID:PMC3828139
DOI:10.1371/journal.pcbi.1003289
Record Number:CaltechAUTHORS:20170405-092056680
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170405-092056680
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75726
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Apr 2017 16:36
Last Modified:15 Nov 2021 16:36

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