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Molecular identification of a retinal cell type that responds to upward motion

Kim, In-Jung and Zhang, Yifeng and Yamagata, Masahito and Meister, Markus and Sanes, Joshua R. (2008) Molecular identification of a retinal cell type that responds to upward motion. Nature, 452 (7186). pp. 478-482. ISSN 0028-0836. http://resolver.caltech.edu/CaltechAUTHORS:20170405-094857083

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Abstract

The retina contains complex circuits of neurons that extract salient information from visual inputs. Signals from photoreceptors are processed by retinal interneurons, integrated by retinal ganglion cells (RGCs) and sent to the brain by RGC axons. Distinct types of RGC respond to different visual features, such as increases or decreases in light intensity (ON and OFF cells, respectively), colour or moving objects1, 2, 3, 4, 5. Thus, RGCs comprise a set of parallel pathways from the eye to the brain. The identification of molecular markers for RGC subsets will facilitate attempts to correlate their structure with their function, assess their synaptic inputs and targets, and study their diversification. Here we show, by means of a transgenic marking method, that junctional adhesion molecule B (JAM-B) marks a previously unrecognized class of OFF RGCs in mice. These cells have asymmetric dendritic arbors aligned in a dorsal-to-ventral direction across the retina. Their receptive fields are also asymmetric and respond selectively to stimuli moving in a soma-to-dendrite direction; because the lens reverses the image of the world on the retina, these cells detect upward motion in the visual field. Thus, JAM-B identifies a unique population of RGCs in which structure corresponds remarkably to function.


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http://dx.doi.org/10.1038/nature06739DOIArticle
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ORCID:
AuthorORCID
Meister, Markus0000-0003-2136-6506
Additional Information:© 2008 Nature Publishing Group. Received 13 September; accepted 24 January 2008. We thank S. Dymecki for FlpE mice, A. Basbaum for WGA mice and U. Dräger, S. Haddad, B. Howell, A. Koizumi, T. Kummer, J. Livet, D. Pelusi and E. Soucy for advice and assistance. This work was supported by grants from the National Institutes of Health to M.M. and J.R.S., a Merck Award and a Bushrod H. Campbell and Adah F. Hall Charity Fund Fellowship to I.J.K., and a Damon Runyon fellowship to Y.Z. Author Contributions: I.J.K., Y.Z., M.Y., M.M. and J.R.S. conceived the experiments. I.J.K and M.Y. performed molecular and histological experiments. Y.Z. performed physiological experiments. Y.Z. and M.M. performed computational analysis. M.M. and J.R.S. wrote the paper.
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Funding AgencyGrant Number
NIHUNSPECIFIED
MerckUNSPECIFIED
Hall Charity FundUNSPECIFIED
Damon Runyon Cancer Research FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20170405-094857083
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20170405-094857083
Official Citation:Molecular identification of a retinal cell type that responds to upward motion In-Jung Kim, Yifeng Zhang, Masahito Yamagata, Markus Meister & Joshua R. Sanes Nature 452, 478-482 (27 March 2008) | doi:10.1038/nature06739
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75728
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:05 Apr 2017 17:34
Last Modified:05 Apr 2017 17:34

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