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The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides

Fahnestock, Margaret L. and Johnson, Jennifer L. and Feldman, R. M. Renny and Neveu, John M. and Lane, William S. and Bjorkman, Pamela J. (1995) The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides. Immunity, 3 (5). pp. 583-590. ISSN 1074-7613. doi:10.1016/1074-7613(95)90129-9.

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The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class 1 molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.

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Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 1995 Cell Press. Received 19 July 1995, Revised 7 September 1995. We thank D. Spector for the DNA encoding UL 18; A. Chirino for help with Figure 1; T. Chapman for providing purified UL 18 and for many helpful discussions; R. Robinson, E. Spooner, and V. Bailey for expertise in HPLC, mass spectrometry, and sequencing; the Caltech microchemical facility and colleagues in the Bjorkman lab for critical reading of the manuscript. This work was supported by the Howard Hughes Medical Institute (M.L.F., J.L.J., P.J.B.) and the Arthritis Foundation (P.J.B.).
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Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20170405-152523311
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Official Citation:Margaret L. Fahnestock, Jennifer L. Johnson, R.M. Renny Feldman, John M. Neveu, William S. Lane, Pamela J. Bjorkman, The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides, Immunity, Volume 3, Issue 5, 1995, Pages 583-590, ISSN 1074-7613, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75752
Deposited By: Tony Diaz
Deposited On:05 Apr 2017 22:48
Last Modified:15 Nov 2021 16:36

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