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MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions

Bjorkman, Pamela J. (1997) MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions. Cell, 89 (2). pp. 167-170. ISSN 0092-8674. https://resolver.caltech.edu/CaltechAUTHORS:20170405-155807900

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Abstract

B and T lymphocytes of the immune system employ a highly effective diversity-generating machinery to ensure that their receptors, antibodies and T cell receptors (TCRs), respectively, have the capacity to recognize an enormous array of antigens. Indeed, antibodies can be raised against many kinds of molecules that are perceived as foreign to the host, including proteins, carbohydrates, small organic compounds, and nucleic acids. TCRs, on the other hand, have the seemingly peculiar property that they only recognize a foreign antigen when it is associated with a host- or “self”-encoded protein called a major histocompatibility complex (MHC) molecule. The T cell property of “MHC-restricted” recognition of antigen was discovered for cytotoxic T cells by Zinkernagel and Doherty 1974, work for which they received the 1996 Nobel Prize in Medicine.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0092-8674(00)80195-6DOIArticle
http://www.sciencedirect.com/science/article/pii/S0092867400801956PublisherArticle
ORCID:
AuthorORCID
Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 1997 Cell Press.
Issue or Number:2
Record Number:CaltechAUTHORS:20170405-155807900
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170405-155807900
Official Citation:Pamela J Bjorkman, MHC Restriction in Three Dimensions: A View of T Cell Receptor/Ligand Interactions, Cell, Volume 89, Issue 2, 18 April 1997, Pages 167-170, ISSN 0092-8674, http://dx.doi.org/10.1016/S0092-8674(00)80195-6. (http://www.sciencedirect.com/science/article/pii/S0092867400801956)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75756
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Apr 2017 23:02
Last Modified:03 Oct 2019 16:53

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