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TCR Recognition and Selection In Vivo

Davis, M. M. and Berg, L. J. and Lin, A. Y. and Fazekas de St. Groth, B. and Devaux, B. and Sagerstrom, C. G. and Bjorkman, P. J. and Elliott, J. F. (1989) TCR Recognition and Selection In Vivo. Cold Spring Harbor Symposia on Quantitative Biology, 54 . pp. 119-128. ISSN 0091-7451. doi:10.1101/SQB.1989.054.01.015.

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Much has been accomplished in identifying the molecules and genes responsible for T-cell recognition. We are now familiar with two distinct heterodimers, αβ and γδ, and we know that the former (at least) confers on a T cell the ability to recognize antigens complexed with specific molecules of the major histocompatibility complex (MHC) (Dembic et al. 1986; Saito and Germain 1987). Because of the recent solution of an MHC class I structure (Bjorkman et al. 1987a,b), its apparent generalization to class II molecules (Brown et al. 1988), as well as the similarity of T-cell receptor (TCR) primary sequences to immunoglobulins (Igs), we can guess a great deal about how they might interact (Chothia et al. 1988, Claverie et al. 1989; Davis and Bjorkman 1988; see also Bjorkman and Davis, this volume).

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Bjorkman, P. J.0000-0002-2277-3990
Additional Information:© 1989 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License, We wish to thank Dr. J. Bangs for advice concerning PtdIns-linked proteins, Angela Nervi for excellent technical assistance, and Brenda Robertson for preparation of the manuscript. We also thank National Institutes of Health for grant support. M.M.D. is a scholar of the Pew Foundation, L.J.B. is a fellow of the Leukemia Society of Anemia, and A.L. was previously a fellow of the Cancer Research Institute and is now supported by the Howard Hughes Medical Institute. S.G. was supported by an Irvington House postdoctoral fellowship and is now supported by a fellowship from the Medical Research Council of Australia. P.J.B. was supported by an American Cancer Society postdoctoral fellowship, and J.F.E. is a centennial fellow of the Medical Research Council of Canada.
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Cancer Research InstituteUNSPECIFIED
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Irvington HouseUNSPECIFIED
Medical Research Council (Australia)UNSPECIFIED
American Cancer SocietyUNSPECIFIED
Leukemia Society of AmericaUNSPECIFIED
Medical Research Council of CanadaUNSPECIFIED
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Official Citation:TCR Recognition and Selection In Vivo M.M. Davis, L.J. Berg, A.Y. Lin, B. Fazekas de St. Groth, B. Devaux, C.G. Sagerstrom, P.J. Bjorkman, and J.F. Elliott Cold Spring Harb Symp Quant Biol 1989 54: 119-128; doi:10.1101/SQB.1989.054.01.015
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75789
Deposited By: Ruth Sustaita
Deposited On:06 Apr 2017 16:40
Last Modified:15 Nov 2021 16:36

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