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Unusual MHC-like molecules; CD1, Fc receptor, the hemochromatosis gene product, and viral homologs

Wilson, Ian A. and Bjorkman, Pamela J. (1998) Unusual MHC-like molecules; CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. Current Opinion in Immunology, 10 (1). pp. 67-73. ISSN 0952-7915. https://resolver.caltech.edu/CaltechAUTHORS:20170406-102036110

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Abstract

The MHC fold, with its well-characterized peptide-binding groove, can perform other functions in addition to presentation of antigenic peptides to T cells. Homologs of MHC molecules have diverse roles that include presentation of lipid antigens (by CD1), transport of immunoglobulins (by the hemochromatosis gene product, HFE), and deception of the host immune system (by viral homologs). Recent crystal structures of two of these non-standard MHC-like molecules have allowed comparison of the recognition properties of classical MHC molecules with those of their unusual homologs.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/S0952-7915(98)80034-4DOIArticle
http://www.sciencedirect.com/science/article/pii/S0952791598800344PublisherArticle
ORCID:
AuthorORCID
Bjorkman, Pamela J.0000-0002-2277-3990
Additional Information:© 1998 Elsevier Ltd. We thank Brent Segelke for the CDI figures. MHC-related work in the authors' laboratories is supported by grants from the National Institutes of Health (CA58896) (to IAW), and (AI/GM 41239) (to PJB), the Howard Hughes Medical Institute (to PJB), and the Arthritis Foundation (to PJB). This is publication number 11291-MB from The Scripps Research Institute.
Funders:
Funding AgencyGrant Number
NIHCA58896
NIHAI/GM41239
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Arthritis FoundationUNSPECIFIED
Issue or Number:1
Record Number:CaltechAUTHORS:20170406-102036110
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170406-102036110
Official Citation:Ian A Wilson, Pamela J Bjorkman, Unusual MHC-like molecules; CD1, Fc receptor, the hemochromatosis gene product, and viral homologs, Current Opinion in Immunology, Volume 10, Issue 1, February 1998, Pages 67-73, ISSN 0952-7915, http://dx.doi.org/10.1016/S0952-7915(98)80034-4. (http://www.sciencedirect.com/science/article/pii/S0952791598800344)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75797
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:06 Apr 2017 17:57
Last Modified:03 Oct 2019 16:54

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