Wilson, Ian A. and Bjorkman, Pamela J. (1998) Unusual MHC-like molecules; CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. Current Opinion in Immunology, 10 (1). pp. 67-73. ISSN 0952-7915. doi:10.1016/S0952-7915(98)80034-4. https://resolver.caltech.edu/CaltechAUTHORS:20170406-102036110
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Abstract
The MHC fold, with its well-characterized peptide-binding groove, can perform other functions in addition to presentation of antigenic peptides to T cells. Homologs of MHC molecules have diverse roles that include presentation of lipid antigens (by CD1), transport of immunoglobulins (by the hemochromatosis gene product, HFE), and deception of the host immune system (by viral homologs). Recent crystal structures of two of these non-standard MHC-like molecules have allowed comparison of the recognition properties of classical MHC molecules with those of their unusual homologs.
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| Additional Information: | © 1998 Elsevier Ltd. We thank Brent Segelke for the CDI figures. MHC-related work in the authors' laboratories is supported by grants from the National Institutes of Health (CA58896) (to IAW), and (AI/GM 41239) (to PJB), the Howard Hughes Medical Institute (to PJB), and the Arthritis Foundation (to PJB). This is publication number 11291-MB from The Scripps Research Institute. | ||||||||||
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| Issue or Number: | 1 | ||||||||||
| DOI: | 10.1016/S0952-7915(98)80034-4 | ||||||||||
| Record Number: | CaltechAUTHORS:20170406-102036110 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170406-102036110 | ||||||||||
| Official Citation: | Ian A Wilson, Pamela J Bjorkman, Unusual MHC-like molecules; CD1, Fc receptor, the hemochromatosis gene product, and viral homologs, Current Opinion in Immunology, Volume 10, Issue 1, February 1998, Pages 67-73, ISSN 0952-7915, http://dx.doi.org/10.1016/S0952-7915(98)80034-4. (http://www.sciencedirect.com/science/article/pii/S0952791598800344) | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 75797 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | Ruth Sustaita | ||||||||||
| Deposited On: | 06 Apr 2017 17:57 | ||||||||||
| Last Modified: | 15 Nov 2021 16:36 |
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