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Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes

Bjorkman, P. J. and Davis, M. M. (1989) Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes. Cold Spring Harbor Symposia on Quantitative Biology, 54 . pp. 365-373. ISSN 0091-7451. doi:10.1101/SQB.1989.054.01.045.

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The immune response against a viral infection is mediated by two different types of cells known as B and T lymphocytes. The receptor on the B cell is the well-characterized antibody molecule, which exists in a membrane-bound form and in a secreted form involved in the initiation of complement-mediated killing and the inactivation of viral particles by direct binding. The recognition molecule on T cells is the membrane-bound T-cell antigen receptor, which has specificity for a combination of foreign antigen with a molecule of the major histocompatibility complex (MHC), as first demonstrated by Zinkernagel and Doherty (1974). MHC proteins exist in two closely related forms called class I and class II MHC molecules, both of which are cell-surface glycoproteins that are highly polymorphic in the human population. In general, class II MHC molecules are involved in interactions with T-helper cells, which cooperate with B cells to make antibody.

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Bjorkman, P. J.0000-0002-2277-3990
Additional Information:© 1989 Cold Spring Harbor Laboratory Press. The Authors acknowledge that six months after the full-issue publication date, the Article will be distributed under a Creative Commons CC-BY-NC License (Attribution-NonCommercial 4.0 International License,
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Official Citation:Model for the Interaction of T-cell Receptors with Peptide/MHC Complexes P.J. Bjorkman and M.M. Davis Cold Spring Harb Symp Quant Biol 1989 54: 365-373; doi:10.1101/SQB.1989.054.01.045
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75800
Deposited By: Ruth Sustaita
Deposited On:06 Apr 2017 17:55
Last Modified:15 Nov 2021 16:36

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