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Sources and evolution of human Alu repeated sequences

Britten, Roy J. and Baron, Will F. and Stout, David B. and Davidson, Eric H. (1988) Sources and evolution of human Alu repeated sequences. Proceedings of the National Academy of Sciences of the United States of America, 85 (13). pp. 4770-4774. ISSN 0027-8424. PMCID PMC280517.

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Alu repeated sequences arising in DNA of the human lineage during about the last 30 million years are closely similar to a modern consensus. Alu repeats arising at earlier times share correlated blocks of differences from the current consensus at diagnostic positions in the sequence. Using these 26 positions, we can recognize four subfamilies and the older ones are each successively closer to the 7SL sequence. It appears that there has existed a series of conserved genes that are the primary sources of the Alu repeat family, presumably through retroposition. These genes have probably replaced each other in overlapping relays during the evolution of primates.

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Additional Information:© 1988 by the National Academy of Sciences. Contributed by Roy J. Britten, March 10, 1988. We thank Barbara Barth for sequence entry and manuscript aid; Jerzy Jurka for data before publication and for additional III and IV class Alu repeats; Carl Schmid for prepublication copies of alignments and references during the review process (5); G. Trabuchet for a clone of a gorilla Alu repeat; and J.L. Goldstein, M.A. Lehrman, and D.W. Russell for unpublished Alu sequences. This work was supported by National Institutes of Health Grant GM34031. The publication costs of this article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. §1734 solely to indicate this fact.
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Subject Keywords:interspersed repeat; retroposition; insertion; CpG dinucleotide
Issue or Number:13
PubMed Central ID:PMC280517
Record Number:CaltechAUTHORS:BRIpnas88
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7588
Deposited By: Tony Diaz
Deposited On:09 Mar 2007
Last Modified:02 Oct 2019 23:43

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