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Neuroanatomical substrates of social cognition dysfunction in autism

Pelphrey, Kevin and Adolphs, Ralph and Morris, James P. (2004) Neuroanatomical substrates of social cognition dysfunction in autism. Mental Retardation And Developmental Disabilities Research Reviews, 10 (4). pp. 259-271. ISSN 1080-4013. doi:10.1002/mrdd.20040.

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In this review article, we summarize recent progress toward understanding the neural structures and circuitry underlying dysfunctional social cognition in autism. We review selected studies from the growing literature that has used the functional neuroimaging techniques of cognitive neuroscience to map out the neuroanatomical substrates of social cognition in autism. We also draw upon functional neuroimaging studies with neurologically normal individuals and individuals with brain lesions to highlight the insights these studies offer that may help elucidate the search for the neural basis of social cognition deficits in autism. We organize this review around key brain structures that have been implicated in the social cognition deficits in autism: (1) the amygdala, (2) the superior temporal sulcus region, and (3) the fusiform gyrus. We review some of what is known about the contribution of each structure to social cognition and then review autism studies that implicate that particular structure. We conclude with a discussion of several potential future directions in the cognitive neuroscience of social deficits in autism.

Item Type:Article
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Adolphs, Ralph0000-0002-8053-9692
Additional Information:© 2004 Wiley-Liss. Manuscript Received: 17 November 2004. Manuscript Accepted: 22 November 2004. Version of record online: 21 January 2005. Special Issue: An Update on Autism Research Grant sponsor: North Carolina Studies to Advance Autism Research and Treatment Center, NIH; Grant number: 1 U54 MH66418. Grant sponsor: NIMH; Grant number: 1 K01 MH071284–0 (to KP).
Funding AgencyGrant Number
NIH1 U54 MH66418
NIH1 K01 MH071284–0
Subject Keywords:autism; social perception; social cognition; functional MRI; cognitive neuroscience
Issue or Number:4
Record Number:CaltechAUTHORS:20170408-143512836
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Official Citation:Pelphrey, K., Adolphs, R. and Morris, J. P. (2004), Neuroanatomical substrates of social cognition dysfunction in autism. Ment. Retard. Dev. Disabil. Res. Rev., 10: 259–271. doi:10.1002/mrdd.20040
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:75972
Deposited By: 1Science Import
Deposited On:25 Apr 2017 22:33
Last Modified:15 Nov 2021 16:56

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