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Protein synthesis in the dendrite

Tang, Shao Jun and Schuman, Erin M. (2002) Protein synthesis in the dendrite. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 357 (1420). pp. 521-529. ISSN 0962-8436. PMCID PMC1692956. doi:10.1098/rstb.2001.0887.

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In neurons, many proteins that are involved in the transduction of synaptic activity and the expression of neural plasticity are specifically localized at synapses. How these proteins are targeted is not clearly understood. One mechanism is synaptic protein synthesis. According to this idea, messenger RNA (mRNA) translation from the polyribosomes that are observed at the synaptic regions provides a local source of synaptic proteins. Although an increasing number of mRNA species has been detected in the dendrite, information about the synaptic synthesis of specific proteins in a physiological context is still limited. The physiological function of synaptic synthesis of specific proteins in synaptogenesis and neural plasticity expression remains to be shown. Experiments aimed at understanding the mechanisms and functions f synaptic protein synthesis might provide important information about the molecular nature of neural plasticity.

Item Type:Article
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URLURL TypeDescription CentralArticle
Schuman, Erin M.0000-0002-7053-1005
Additional Information:© 2002 The Royal Society. Received 5 April 2000. Accepted 7 September 2000. Published online 22 April 2002.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Subject Keywords:neuron; dendrite; synapse; messenger RNA; protein synthesis; synaptic plasticity
Issue or Number:1420
PubMed Central ID:PMC1692956
Record Number:CaltechAUTHORS:20170408-144848727
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Official Citation:Protein synthesis in the dendrite Shao Jun Tang, Erin M. Schuman Phil. Trans. R. Soc. Lond. B 2002 357 521-529; DOI: 10.1098/rstb.2001.0887. Published 29 April 2002
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76013
Deposited By: 1Science Import
Deposited On:04 May 2017 22:05
Last Modified:15 Nov 2021 16:56

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