A Caltech Library Service

The Role of CREB as a Proto-oncogene in Hematopoiesis

Kinjo, Kentaro and Sandoval, Salemiz and Sakamoto, Kathleen M. and Shankar, Deepa B. (2005) The Role of CREB as a Proto-oncogene in Hematopoiesis. Cell Cycle, 4 (9). pp. 1134-1135. ISSN 1538-4101. doi:10.4161/cc.4.9.1991.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Cyclic-AMP response element binding protein (CREB) is a transcription factor that functions in glucose homeostasis, growth-factor- dependent cell survival, proliferation and memory. Signaling by hematopoietic growth factors, such as GM-CSF, results in activation of CREB and upregulation of CREB target genes. Data from our laboratory shows that a majority of patients with acute lymphoid and myeloid leukemiaoverexpress CREB in the bone marrow. CREB overexpression is associated with poor initial outcome of clinical disease in AML patients. To study its role in hematopoiesis, we overexpressed CREB in leukemia cell lines and in mice. CREB overexpression resulted in increased survival and proliferation of myeloid cells and blast-transformation of bone marrow progenitor cells from transgenic mice expressing CREB in the myeloid lineage. CREB transgenic mice also develop myeloproliferative disease after one year. Thus, CREB acts as a proto-oncogene to regulate hematopoiesis and contributes to the leukemia phenotype. Our results suggest that CREB-dependent pathways may serve as targets for directed therapies in leukemia in the future.

Item Type:Article
Related URLs:
URLURL TypeDescription
Sakamoto, Kathleen M.0000-0003-0494-8838
Additional Information:© 2005 Landes Bioscience. Received 07/01/05; Accepted 07/06/05.
Subject Keywords:CREB, proto-oncogene, hematopoiesis, transcription factor, acute myeloid leukemia
Issue or Number:9
Record Number:CaltechAUTHORS:20170408-144940054
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76018
Deposited By: 1Science Import
Deposited On:04 May 2017 22:20
Last Modified:15 Nov 2021 16:56

Repository Staff Only: item control page