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Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus

Scherberger, H. and Fineman, I. and Musallam, S. and Dubowitz, D. J. and Bernheim, K. A. and Pesaran, B. and Corneil, B. D. and Gilliken, B. and Andersen, R. A. (2003) Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus. Journal of Neuroscience Methods, 130 (1). pp. 1-8. ISSN 0165-0270. https://resolver.caltech.edu/CaltechAUTHORS:20170408-151130086

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Abstract

The implantation of chronic recording electrodes in the brain has been shown to be a valuable method for simultaneously recording from many neurons. However, precise placement of these electrodes, crucial for successful recording, is challenging if the target area is not on the brain surface. Here we present a stereotaxic implantation procedure to chronically implant bundles of recording electrodes into macaque cortical sulci, employing magnetic resonance (MR) imaging to determine stereotaxic coordinates of target location and sulcus orientation. Using this method in four animals, we recorded simultaneously the spiking activity and the local field potential from the parietal reach region (PRR), located in the medial bank of the intraparietal sulcus (IPS), while the animal performed a reach movement task. Fifty percent of all electrodes recorded spiking activity during the first 2 post-operative months, indicating their placement within cortical gray matter. Chronic neural activity was similar to standard single electrode recordings in PRR, as reported previously. These results indicate that this MR image-guided implantation technique can provide sufficient placement accuracy in cortical sulci and subcortical structures. Moreover, this technique may be useful for future cortical prosthesis applications in humans that require implants within sulci.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/S0165-0270(03)00190-0DOIArticle
Additional Information:© 2003 Elsevier. Received 13 March 2003, Revised 6 June 2003, Accepted 10 June 2003, Available online 24 September 2003. We thank K. Weaver for animal care, R. Bhattacharyya, B. Greger and V. Shcherbatyuk for technical support, and A. Schwartz, and J. Williams for early, helpful discussions. This work was supported by the Christopher Reeve Paralysis Foundation (HS), the Human Frontier Science Program (BDC), the James G. Boswell Foundation, the Defense Advanced Research Projects Agency, and the National Eye Institute.
Funders:
Funding AgencyGrant Number
Christopher Reeve Paralysis FoundationUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
James G. Boswell FoundationUNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
National Eye InstituteUNSPECIFIED
NIHUNSPECIFIED
Subject Keywords:Microwire electrodes; Magnetic resonance imaging; Parietal cortex; Neural prosthesis
Issue or Number:1
Record Number:CaltechAUTHORS:20170408-151130086
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170408-151130086
Official Citation:H Scherberger, I Fineman, S Musallam, D.J Dubowitz, K.A Bernheim, B Pesaran, B.D Corneil, B Gilliken, R.A Andersen, Magnetic resonance image-guided implantation of chronic recording electrodes in the macaque intraparietal sulcus, Journal of Neuroscience Methods, Volume 130, Issue 1, 30 November 2003, Pages 1-8, ISSN 0165-0270, https://doi.org/10.1016/S0165-0270(03)00190-0. (http://www.sciencedirect.com/science/article/pii/S0165027003001900)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76038
Collection:CaltechAUTHORS
Deposited By: 1Science Import
Deposited On:05 May 2017 23:19
Last Modified:03 Oct 2019 16:57

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