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Clock mutants of Drosophila melanogaster

Konopka, Ronald J. and Benzer, Seymour (1971) Clock mutants of Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America, 68 (9). pp. 2112-2116. ISSN 0027-8424. PMCID PMC389363.

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Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed. One mutant is arrhythmic; another has a period of 19 hr; a third has a period of 28 hr. Both the eclosion rhythm of a population and the locomotor activity of individual flies are affected. All these mutations appear to involve the same functional gene on the X chromosome.

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Additional Information:© 1971 by the National Academy of Sciences. Contributed by Seymour Benzer, July 2, 1971. This work was supported by a grant from the National Science Foundation to S.B. and a National Science Foundation predoctoral fellowship to R.K. We thank Dr. Colin Pittendrigh for enlightening discussions and for the loan of several bang boxes, Dr. Yoshiki Hotta for design and construction of the activity detectors, and Barbara Stewart for help with the mapping experiments.
Funding AgencyGrant Number
NSF Graduate Research FellowshipUNSPECIFIED
Subject Keywords:eclosion; circadian; rhythms; X chromosome
Issue or Number:9
PubMed Central ID:PMC389363
Record Number:CaltechAUTHORS:KONpnas71
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Official Citation:Clock Mutants of Drosophila melanogaster Ronald J. Konopka, Seymour Benzer Proceedings of the National Academy of Sciences Sep 1971, 68 (9) 2112-2116; DOI: 10.1073/pnas.68.9.2112
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7605
Deposited By: Tony Diaz
Deposited On:13 Mar 2007
Last Modified:02 Oct 2019 23:43

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