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MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients

Wood, John C. and Enriquez, Cathleen and Ghugre, Nilesh and Tyzka, J. Michael and Carson, Susan and Nelson, Marvin D. and Coates, Thomas D. (2005) MRI R2 and R2* mapping accurately estimates hepatic iron concentration in transfusion-dependent thalassemia and sickle cell disease patients. Blood, 106 (4). pp. 1460-1465. ISSN 0006-4971. PMCID PMC1895207. doi:10.1182/blood-2004-10-3982.

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Measurements of hepatic iron concentration (HIC) are important predictors of transfusional iron burden and long-term outcome in patients with transfusion-dependent anemias. The goal of this work was to develop a readily available, noninvasive method for clinical HIC measurement. The relaxation rates R2 (1/T2) and R2* (1/T2*) measured by magnetic resonance imaging (MRI) have different advantages for HIC estimation. This article compares noninvasive iron estimates using both optimized R2 and R2* methods in 102 patients with iron overload and 13 controls. In the iron-overloaded group, 22 patients had concurrent liver biopsy. R2 and R2* correlated closely with HIC (r2 ≥ .95) for HICs between 1.33 and 32.9 mg/g, but R2 had a curvilinear relationship to HIC. Of importance, the R2 calibration curve was similar to the curve generated by other researchers, despite significant differences in technique and instrumentation. Combined R2 and R2* measurements did not yield more accurate results than either alone. Both R2 and R2* can accurately measure hepatic iron concentration throughout the clinically relevant range of HIC with appropriate MRI acquisition techniques.

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Additional Information:© 2005 by The American Society of Hematology. Submitted October 18, 2004; accepted April 15, 2005. Prepublished online as Blood First Edition Paper, April 28, 2005; DOI 10.1182/blood-2004-10-3982. Supported by the National Heart, Lung and Blood Institute (1R01 HL75592-01A1) and the National Center for Research Resources (General Clinical Research Center [GCRC] RR00043-43) at the National Institutes of Health as well as Novartis Pharma, the Whitaker Foundation, and the Department of Pediatrics at Children’s Hospital of Los Angeles. The publication costs of this article were defrayed in part by page charge payment. Therefore, and solely to indicate this fact, this article is hereby marked "advertisement" in accordance with 18 U.S.C. section 1734.
Funding AgencyGrant Number
NIH1R01 HL75592-01A1
Novartis PharmaUNSPECIFIED
Whitaker FoundationUNSPECIFIED
Children's Hospital of Los AngelesUNSPECIFIED
Issue or Number:4
PubMed Central ID:PMC1895207
Record Number:CaltechAUTHORS:20170408-154843856
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76072
Deposited By: 1Science Import
Deposited On:24 May 2017 00:16
Last Modified:15 Nov 2021 16:57

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