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The inadequacy of the sub-gene hypothesis of the nature of the scute allelomorphs of Drosophila

Sturtevant, A. H. and Schultz, Jack (1931) The inadequacy of the sub-gene hypothesis of the nature of the scute allelomorphs of Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 17 (5). pp. 265-270. ISSN 0027-8424. PMCID PMC1076041. https://resolver.caltech.edu/CaltechAUTHORS:STUpnas31

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Abstract

In a series of papers, Serebrovsky (1930), Dubinin (1929), Agol (1930) and their colleagues have described an extremely interesting group of bristle-reducing mutant genes lying at the scute locus of the X-chromosome of Drosophila melanogaster. As a result of their careful studies of this material, they have elaborated an interpretation of the situation. According to this hypothesis, the normal allelomorph of the scute genes is not a single unit, but is made up of a series of "sub-genes" arranged in linear order, each sub-gene being concerned with the development of one or of a few bristles on the fly. The scute mutations involve changes in blocks of these sub-genes, but of different blocks. Scute 11, for example, represents mutation of a few sub-genes at the left end of the series; scute 4, of practically all the sub-genes not affected by scute 11; scute 5 of a few sub-genes near the right end. All the known allelomorphs may be described in such terms.


Item Type:Article
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https://doi.org/10.1073/pnas.17.5.265DOIArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/pmc1076041/PubMed CentralArticle
Additional Information:© 1931 by the National Academy of Sciences. Communicated April 2, 1931. We are greatly indebted to Prof. A. S. Serebrovsky for his generosity in sending to this laboratory stocks of scute 2, scute 3, scute 4, scute 5, scute 6, scute 7 and scute 11, as well as of several other interesting new types. The other types examined were scute 1, scute B3 (the scute 3 of Morgan, Bridges and Sturtevant, 1925), achaete, and scute D (recently obtained by Prof. T. Dobzhansky in x-ray experiments, and very kindly given to us by him). It is a pleasure to express our indebtedness to Professor H. J. Muller, to Professor T. Dobzhansky and to L. V. Morgan, for their kindness in supplying us with stocks of the various duplications.
Issue or Number:5
PubMed Central ID:PMC1076041
Record Number:CaltechAUTHORS:STUpnas31
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:STUpnas31
Official Citation:The Inadequacy of the Sub-Gene Hypothesis of the Nature of the Scute Allelomorphs of Drosophila A. H. Sturtevant, Jack Schultz Proceedings of the National Academy of Sciences May 1931, 17 (5) 265-270; DOI: 10.1073/pnas.17.5.265
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7610
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:13 Mar 2007
Last Modified:15 May 2020 18:25

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