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Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations

Wilke, Claus O. and Reissig, Daniel D. and Novella, Isabel S. (2004) Replication at periodically changing multiplicity of infection promotes stable coexistence of competing viral populations. Evolution, 58 (4). pp. 900-905. ISSN 1558-5646. https://resolver.caltech.edu/CaltechAUTHORS:20170408-164157361

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Abstract

RNA viruses are widely used to study evolution experimentally. Many standard protocols of virus propagation and competition are done at nominally low multiplicity of infection (m.o.i.), but lead during one passage to two or more rounds of infection, of which the later ones are at high m.o.i. Here, we develop a model of the competition between wild type (wt) and a mutant under a regime of alternating m.o.i. We assume that the mutant is deleterious when it infects cells on its own, but derives a selective advantage when rare and coinfecting with wt, because it can profit from superior protein products created by the wt. We find that, under these assumptions, replication at alternating low and high m.o.i. may lead to the stable coexistence of wt and mutant for a wide range of parameter settings. The predictions of our model are consistent with earlier observations of frequency-dependent selection in vesicular stomatitis virus and human immunodeficiency virus type 1. Our results suggest that frequency-dependent selection may be common in typical evolution experiments with viruses.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1111/j.0014-3820.2004.tb00422.xDOIArticle
https://arxiv.org/abs/q-bio/0402010arXivDiscussion Paper
ORCID:
AuthorORCID
Wilke, Claus O.0000-0002-7470-9261
Additional Information:© 2004 The Society for the Study of Evolution. Received November 10, 2003. Accepted November 18, 2003. COW was supported by the National Science Foundation under contract DEB-9981397 to C. Adami. ISN was supported by National Institutes of Health grant AI45686.
Funders:
Funding AgencyGrant Number
NSFDEB-9981397
NIHAI45686
Subject Keywords:Complementation; experimental evolution; frequency-dependent selection; quasispecies; vesicular stomatitis virus
Issue or Number:4
Record Number:CaltechAUTHORS:20170408-164157361
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170408-164157361
Official Citation:Wilke, C. O., Reissig, D. D. and Novella, I. S. (2004), REPLICATION AT PERIODICALLY CHANGING MULTIPLICITY OF INFECTION PROMOTES STABLE COEXISTENCE OF COMPETING VIRAL POPULATIONS. Evolution, 58: 900–905. doi:10.1111/j.0014-3820.2004.tb00422.x
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76234
Collection:CaltechAUTHORS
Deposited By: 1Science Import
Deposited On:09 Mar 2018 17:57
Last Modified:03 Oct 2019 16:58

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