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Mitochondrial Fusion and Fission in Mammals

Chan, David C. (2007) Mitochondrial Fusion and Fission in Mammals. Annual Review of Cell and Developmental Biology, 22 . pp. 79-99. ISSN 1081-0706. https://resolver.caltech.edu/CaltechAUTHORS:CHAarcdb06

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Abstract

Eukaryotic cells maintain the overall shape of their mitochondria by balancing the opposing processes of mitochondrial fusion and fission. Unbalanced fission leads to mitochondrial fragmentation, and unbalanced fusion leads to mitochondrial elongation. Moreover, these processes control not only the shape but also the function of mitochondria. Mitochondrial dynamics allows mitochondria to interact with each other; without such dynamics, the mitochondrial population consists of autonomous organelles that have impaired function. Key components of the mitochondrial fusion and fission machinery have been identified, allowing initial dissection of their mechanisms of action. These components play important roles in mitochondrial function and development as well as programmed cell death. Disruption of the fusion machinery leads to neurodegenerative disease.


Item Type:Article
Additional Information:"Reprinted, with permission, from the Annual Review of Cell and Developmental Biology, Volume 22 copyright 2006 by Annual Reviews, www.annualreviews.org" First published online as a Review in Advance on May 11, 2006. I am grateful to Hsiuchen Chen for helpful comments on the manuscript. Work in my laboratory is supported by the NIH (GM062967), the Muscular Dystrophy Association, and the United Mitochondrial Disease Foundation.
Subject Keywords:mitochondrial dynamics, organelle morphology, membrane fusion, membrane trafficking
Record Number:CaltechAUTHORS:CHAarcdb06
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:CHAarcdb06
Alternative URL:http://dx.doi.org/10.1146/annurev.cellbio.22.010305.104638
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7638
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:15 Mar 2007
Last Modified:02 Oct 2019 23:44

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