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Distribution and localization of a G protein-coupled inwardly rectifying K^+ channel in the rat

Karschin, Christine and Schreibmayer, Wolfgang and Dascal, Nathan and Lester, Henry and Davidson, Norman and Karschin, Andreas (1994) Distribution and localization of a G protein-coupled inwardly rectifying K^+ channel in the rat. FEBS Letters, 348 (2). pp. 139-144. ISSN 0014-5793. https://resolver.caltech.edu/CaltechAUTHORS:20170408-205029469

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Abstract

The cellular distribution of the mRNA of the inwardly rectifying K^+ channel KGA (GIRK1) was investigated in rat tissue by in situ hybridization. KGA was originally cloned from the heart and represents the first G protein‐activated K^+ channel identified. It is expressed in peripheral tissue solely in the atrium, but not in the ventricle, skeletal muscle, lung and kidney. In the central nervous system KGA is most prominently expressed in the Ammon's horn and dentate gyrus of the hippocampus, neocortical layers II–VI, cerebellar granular layer, olfactory bulb, anterior pituitary, thalamic nuclei and several distinct nuclei of the lower brainstem. The abundant expression of KGA in many CNS neurons support its important role as a major target channel for G protein mediated receptor function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/0014-5793(94)00590-7DOIArticle
ORCID:
AuthorORCID
Lester, Henry0000-0002-5470-5255
Alternate Title:Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat
Additional Information:© 1994 Federation of European Biochemical Societies. Manuscript received: 07 April 1994. Manuscript revised: 31 May 1994. We wish to thank Dr. Walter Stühmer for hisgenerous support. The study was supported in part by grants from the US National Institutes of Health (GM-29836, MH-49176), the US-Israel Binational Science Foundation, the Austrian Research Foundation and the Human Frontiers Organization.
Funders:
Funding AgencyGrant Number
NIHGM-29836
NIHMH-49176
Binational Science Foundation (USA-Israel)UNSPECIFIED
FWF Der WissenschaftsfondsUNSPECIFIED
Human Frontier Science ProgramUNSPECIFIED
Subject Keywords:Potassium channel; Inward rectifier; G-protein gating; mRNA; Hybridization (in situ)
Issue or Number:2
Record Number:CaltechAUTHORS:20170408-205029469
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170408-205029469
Official Citation:Karschin Christine,Schreibmayer Wolfgang,Dascal Nathan,Lester Henry,Davidson Norman and Karschin Andreas(1994), Distribution and localization of a G protein-coupled inwardly rectifying K+ channel in the rat, FEBS Letters, 348, doi: 10.1016/0014-5793(94)00590-7
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76393
Collection:CaltechAUTHORS
Deposited By: 1Science Import
Deposited On:30 Mar 2018 23:35
Last Modified:03 Oct 2019 17:00

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