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COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor

Selitrennikoff, C. P. and Alex, L. and Miller, T. K. and Clemons, K. V. and Simon, M. I. and Stevens, D. A. (2001) COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor. Medical Mycology, 39 (1). pp. 69-74. ISSN 1369-3786. https://resolver.caltech.edu/CaltechAUTHORS:20170408-211822984

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Abstract

The human fungal pathogen, Candida albicans, has three putative histidine kinases showing homology to those of plants, bacteria and other fungi. We have constructed a homozygous deletion strain and a hemizygous reconstituted strain of one of these histidine-kinase-encoding genes, COS-1, in C. albicans. Neither strain showed any growth defect in a number of liquid media nor increased resistance or sensitivity to a number of antifungal drugs. Importantly, we show that the COS-1 homozygous disruption strain had significantly reduced virulence in a systemic murine model of candidosis. Thus, COS-1 appears to be an in vivo virulence factor and may represent a novel target for the development of antifungal drugs.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1080/mmy.39.1.69.74DOIArticle
Additional Information:© 2001 ISHAM. The authors express thanks to Ms K. Chilson for her unpublished results concerning the antifungal sensitivities of various C. albicans strains. This work was supported in part by NIH RO1 award AI 33354 (C. P. Selitrennikoff) and NIH award AI 19296 (M. I. Simon).
Funders:
Funding AgencyGrant Number
NIHRO1 AI 33354
NIHAI 19296
Subject Keywords:Candida albicans, COS-1, in vivo virulence, two-component histidine kinases
Issue or Number:1
Record Number:CaltechAUTHORS:20170408-211822984
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170408-211822984
Official Citation:C. P. Selitrennikoff, L. Alex, T. K. Miller, K. V. Clemons, M. I. Simon, D. A. Stevens; COS-1, a putative two-component histidine kinase of Candida albicans, is an in vivo virulence factor, Medical Mycology, Volume 39, Issue 1, 1 January 2001, Pages 69–74, https://doi.org/10.1080/mmy.39.1.69.74
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76401
Collection:CaltechAUTHORS
Deposited By: 1Science Import
Deposited On:02 Apr 2018 18:20
Last Modified:03 Oct 2019 17:00

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