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Robustness of Cellular Functions

Stelling, Jörg and Sauer, Uwe and Szallasi, Zoltan and Doyle, Francis J. and Doyle, John (2004) Robustness of Cellular Functions. Cell, 118 (6). pp. 675-685. ISSN 0092-8674. doi:10.1016/j.cell.2004.09.008.

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Robustness, the ability to maintain performance in the face of perturbations and uncertainty, is a long-recognized key property of living systems. Owing to intimate links to cellular complexity, however, its molecular and cellular basis has only recently begun to be understood. Theoretical approaches to complex engineered systems can provide guidelines for investigating cellular robustness because biology and engineering employ a common set of basic mechanisms in different combinations. Robustness may be a key to understanding cellular complexity, elucidating design principles, and fostering closer interactions between experimentation and theory.

Item Type:Article
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URLURL TypeDescription
Doyle, John0000-0002-1828-2486
Additional Information:© 2004 Cell Press. Available online 16 September 2004. This work was supported by the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the U.S. Army Research Office, DARPA BioComp program, and NIH grant R01 GM65507-01 to F.J.D. and by the Kitano ERATO Symbiotic Systems Project and grants from AFOSR, NSF, and DARPA to J.D.
Funding AgencyGrant Number
Army Research Office (ARO)DAAD19-03-D-0004
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
NIHR01 GM65507-01
Kitano ERATO Symbiotic Systems ProjectUNSPECIFIED
Air Force Office of Scientific Research (AFOSR)UNSPECIFIED
Issue or Number:6
Record Number:CaltechAUTHORS:20170408-213739584
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Official Citation:Jörg Stelling, Uwe Sauer, Zoltan Szallasi, Francis J. Doyle, John Doyle, Robustness of Cellular Functions, Cell, Volume 118, Issue 6, 2004, Pages 675-685, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76408
Deposited By: 1Science Import
Deposited On:02 Apr 2018 20:20
Last Modified:15 Nov 2021 16:59

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