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The Kinetics of Analyte Capture on Nanoscale Sensors

Solomon, J. E. and Paul, M. R. (2006) The Kinetics of Analyte Capture on Nanoscale Sensors. Biophysical Journal, 90 (5). pp. 1842-1852. ISSN 0006-3495. PMCID PMC1367333. doi:10.1529/biophysj.105.067835.

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This article presents a number of kinetic analyses related to binding processes relevant to capture of target analyte species in nanoscale cantilever-type devices designed to detect small concentrations of biomolecules. The overall analyte capture efficiency is a crucial measure of the ultimate sensitivity of such devices, and a detailed kinetic analysis tells us how rapidly such measurements may be made. We have analyzed the capture kinetics under a variety of conditions, including the possibility of so-called surface-enhanced ligand capture. One of the modalities studied requires ligand capture through a cross-linking mechanism, and it was found that this mode may provide a robust and sensitive approach to biomolecular detection. For the two modalities studied, we find that detection of specific biomolecules down to concentration levels of 1 nM or less appear to be quite feasible for the device configurations studied.

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Additional Information:© 2006 The Biophysical Society. Published by Elsevier. Received 2 June 2005, Accepted 26 September 2005. The authors gratefully acknowledge numerous useful discussions with various members of this project. We also thank one of the reviewers for several stimulating comments on some important issues related to the analyses presented in this article. This work was partially supported by the Caltech BioNems project (M. L. Roukes, Principal Investigator), funded by Defense Advanced Research Projects Agency Simbiosys under grant No. F49620-02-1-0085.
Funding AgencyGrant Number
Air Force Office of Scientific Research (AFOSR)F49620-02-1-0085
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Issue or Number:5
PubMed Central ID:PMC1367333
Record Number:CaltechAUTHORS:20170409-071006800
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Official Citation:J.E. Solomon, M.R. Paul, The Kinetics of Analyte Capture on Nanoscale Sensors, Biophysical Journal, Volume 90, Issue 5, 2006, Pages 1842-1852, ISSN 0006-3495, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76428
Deposited By: 1Science Import
Deposited On:03 Apr 2018 19:58
Last Modified:15 Nov 2021 16:59

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