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Deployable micro-traps to sequester motile bacteria

Di Giacomo, Raffaele and Krödel, Sebastian and Maresca, Bruno and Benzoni, Patrizia and Rusconi, Roberto and Stocker, Roman and Daraio, Chiara (2017) Deployable micro-traps to sequester motile bacteria. Scientific Reports, 7 . Art. No. 45897. ISSN 2045-2322. https://resolver.caltech.edu/CaltechAUTHORS:20170410-124125950

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Abstract

The development of strategies to reduce the load of unwanted bacteria is a fundamental challenge in industrial processing, environmental sciences and medical applications. Here, we report a new method to sequester motile bacteria from a liquid, based on passive, deployable micro-traps that confine bacteria using micro-funnels that open into trapping chambers. Even in low concentrations, micro-traps afford a 70% reduction in the amount of bacteria in a liquid sample, with a potential to reach >90% as shown by modelling improved geometries. This work introduces a new approach to contain the growth of bacteria without chemical means, an advantage of particular importance given the alarming growth of pan-drug-resistant bacteria.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1038/srep45897DOIArticle
http://www.nature.com/articles/srep45897PublisherArticle
ORCID:
AuthorORCID
Krödel, Sebastian0000-0002-9218-8578
Daraio, Chiara0000-0001-5296-4440
Additional Information:© 2017 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Received: 13 October 2016; Accepted: 28 February 2017; Published: 05 April 2017. The authors thank Assaf Gavish and Assaf Vardi (Weizmann Institute of Science) for providing V. coralliilyticus YB2 dsRed. Funding for this research what partially provided by the Swiss National Science Foundation Grant” MechNanoTruss-Mechanical response of polymer nanotruss scaffolds “(Grant No. 164375). Author Contributions: R.D.G., S.K., B.M., P.B., R.R., R.S. and C.D conceived the idea and designed the research. R.D.G., S.K., P.B. and R.R. performed and analyzed bacteria experiments. R.R. performed and analyzed numerical simulations. R.D.G., S.K., B.M., P.B., R.R., R.S. and C.D. wrote the manuscript. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
Swiss National Science Foundation (SNSF)164375
Record Number:CaltechAUTHORS:20170410-124125950
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170410-124125950
Official Citation:Di Giacomo, R. et al. Deployable micro-traps to sequester motile bacteria. Sci. Rep. 7, 45897; doi: 10.1038/srep45897 (2017)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76476
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:10 Apr 2017 21:22
Last Modified:03 Oct 2019 17:01

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