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A Descending Neuron Correlated with the Rapid Steering Maneuvers of Flying Drosophila

Schnell, Bettina and Ros, Ivo G. and Dickinson, Michael H. (2017) A Descending Neuron Correlated with the Rapid Steering Maneuvers of Flying Drosophila. Current Biology, 27 (8). pp. 1200-1205. ISSN 0960-9822. PMCID PMC6309624. https://resolver.caltech.edu/CaltechAUTHORS:20170411-082920130

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Abstract

To navigate through the world, animals must stabilize their path against disturbances and change direction to avoid obstacles and to search for resources [1 ; 2]. Locomotion is thus guided by sensory cues but also depends on intrinsic processes, such as motivation and physiological state. Flies, for example, turn with the direction of large-field rotatory motion, an optomotor reflex that is thought to help them fly straight [3; 4 ; 5]. Occasionally, however, they execute fast turns, called body saccades, either spontaneously or in response to patterns of visual motion such as expansion [6; 7 ; 8]. These turns can be measured in tethered flying Drosophila [ 3; 4 ; 9], which facilitates the study of underlying neural mechanisms. Whereas there is evidence for an efference copy input to visual interneurons during saccades [10], the circuits that control spontaneous and visually elicited saccades are not well known. Using two-photon calcium imaging and electrophysiological recordings in tethered flying Drosophila, we have identified a descending neuron whose activity is correlated with both spontaneous and visually elicited turns during tethered flight. The cell’s activity in open- and closed-loop experiments suggests that it does not underlie slower compensatory responses to horizontal motion but rather controls rapid changes in flight path. The activity of this neuron can explain some of the behavioral variability observed in response to visual motion and appears sufficient for eliciting turns when artificially activated. This work provides an entry point into studying the circuits underlying the control of rapid steering maneuvers in the fly brain.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cub.2017.03.004DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309624PubMed CentralArticle
ORCID:
AuthorORCID
Ros, Ivo G.0000-0002-9089-548X
Dickinson, Michael H.0000-0002-8587-9936
Additional Information:© 2017 Elsevier Ltd. Received 26 August 2016, Revised 19 January 2017, Accepted 2 March 2017, Available online 6 April 2017Published: April 6, 2017. We would like to thank Ainul Huda and Peter Weir for the image of the R56G08-Gal4 line; Shigehiro Namiki for information about Gal4 lines labeling descending neurons; and Gaby Maimon, Theodore Lindsay, and Peter Weir for comments on the manuscript. This work was supported by the Raymond and Beverly Sackler Foundation (B.S.), the Paul G. Allen Family Foundation (M.H.D.), and the National Institute of Neurological Disorders and Stroke of the NIH under award U01NS090514 (M.H.D). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. Author Contributions: Conceptualization, B.S. and M.H.D.; Methodology, B.S. and I.G.R.; Investigation, B.S. and I.G.R.; Formal Analysis, B.S. and I.G.R.; Writing – Original Draft, B.S. and M.H.D.; Writing – Review & Editing, B.S., I.G.R., and M.H.D.; Funding Acquisition, B.S. and M.H.D.; Supervision, M.H.D. Accession Numbers: Data reported in this manuscript have been deposited at the Dryad Digital Repository: http://dx.doi.org/10.5061/dryad.n7v41.
Funders:
Funding AgencyGrant Number
Raymond and Beverly Sackler FoundationUNSPECIFIED
Paul G. Allen Family FoundationUNSPECIFIED
NIHU01NS090514
Subject Keywords:descending neuron; spontaneous behavior; flight; saccades; Drosophila
Issue or Number:8
PubMed Central ID:PMC6309624
Record Number:CaltechAUTHORS:20170411-082920130
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170411-082920130
Official Citation:Bettina Schnell, Ivo G. Ros, Michael H. Dickinson, A Descending Neuron Correlated with the Rapid Steering Maneuvers of Flying Drosophila, Current Biology, Volume 27, Issue 8, 24 April 2017, Pages 1200-1205, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2017.03.004. (http://www.sciencedirect.com/science/article/pii/S0960982217302737)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76499
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:11 Apr 2017 16:57
Last Modified:03 Oct 2019 17:01

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