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Interhemispheric relationships: the neocortical commissures; syndromes of hemisphere disconnection

Sperry, R. W. and Gazzaniga, M. S. and Bogen, J. E. (1969) Interhemispheric relationships: the neocortical commissures; syndromes of hemisphere disconnection. In: Disorders of speech, perception and symbolic behavior. Handbook of clinical neurology. No.4. North-Holland Publishing Co. , Amsterdam, pp. 273-290. ISBN 9780720472042. https://resolver.caltech.edu/CaltechAUTHORS:20170414-111911293

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Abstract

[Introduction] Until a few years ago, prevailing views regarding the syndrome of the corpus callosum in man were based very largely on the studies of Akelaitis and his co-workers (Akelaitis et al. 1942; Akelaitis 1944). Using a wide variety of tests Akelaitis examined a series of more than two dozen patients with partial and complete surgical sections of the corpus callosum and anterior commissure and was unable to find any consistent neurological or psychological dysfunctions that could be reliably attributed to the commissural sections. Symptoms such as unilateral astereognosis, alexia, agraphia, ideo-motor apraxia (Sweet 1941), as well as apathy, amnesia, personality changes and related effects, that earlier had been ascribed to callosal lesions (Alpers and Grant 1931) seemed accordingly to be more properly explained in terms of the extracallosal cerebral damage that commonly accompanies lesions in the commissures. These Akelaitis reports in combination with confirmatory observations on absence of symptoms after callosum section in animals established the general doctrine of the 1940's and 1950's in which it was believed that behavioral deficits seen in connection with callosal lesions are best ascribed to associated brain damage (Bremer et al. 1956). Meanwhile, the discrepancy between the enormous size and strategic position of the corpus callosum on the one hand and the observed lack of any important functional disturbance following its complete surgical section on the other remained during this period one of the more puzzling enigmas of neurology.


Item Type:Book Section
Additional Information:Copyright North-Holland Publishing Company, Amsterdam, 1969. Sole distribution for the western hemisphere: Wiley Interscience Division, John Wiley & Sons, New York. Preparation of the manuscript and original work cited has been supported by grants to the first author from the National Institute of Mental Health (MH-03372) of the us Public Health Service and by the Hixon Fund of the California Institute of Technology.
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Funding AgencyGrant Number
National Institute of Mental HealthMH- 03372
Hixon Fund (California Institute of Technology)UNSPECIFIED
Series Name:Handbook of clinical neurology
Issue or Number:4
Record Number:CaltechAUTHORS:20170414-111911293
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170414-111911293
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76571
Collection:CaltechAUTHORS
Deposited By: Katherine Johnson
Deposited On:14 Apr 2017 21:18
Last Modified:03 Oct 2019 17:02

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