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Imaging moving targets through scattering media

Cua, Michelle and Zhou, Edward Haojiang and Yang, Changhuei (2017) Imaging moving targets through scattering media. Optics Express, 25 (4). pp. 3935-3945. ISSN 1094-4087. PMCID PMC5772388.

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Optical microscopy in complex, inhomogeneous media is challenging due to the presence of multiply scattered light that limits the depths at which diffraction-limited resolution can be achieved. One way to circumvent the degradation in resolution is to use speckle- correlation-based imaging (SCI) techniques, which permit imaging of objects inside scattering media at diffraction-limited resolution. However, SCI methods are currently limited to imaging sparsely tagged objects in a dark-field scenario. In this work, we demonstrate the ability to image hidden, moving objects in a bright-field scenario. By using a deterministic phase modulator to generate a spatially incoherent light source, the background contribution can be kept constant between acquisitions and subtracted out. In this way, the signal arising from the object can be isolated, and the object can be reconstructed with high fidelity. With the ability to effectively isolate the object signal, our work is not limited to imaging bright objects in the dark-field case, but also works in bright-field scenarios, with non-emitting objects.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Zhou, Edward Haojiang0000-0001-7020-9502
Yang, Changhuei0000-0001-8791-0354
Additional Information:© 2017 Optical Society of America. Received 13 Dec 2016; revised 20 Jan 2017; accepted 21 Jan 2017; published 14 Feb 2017. Funding: National Institutes of Health (NIH 1U01NS090577); GIST-Caltech Collaborative Research (CG2016); Natural Sciences and Engineering Research Council of Canada (NSERC PGSD3). The authors would like to thank Joshua Brake for helpful feedback on the manuscript.
Funding AgencyGrant Number
GIST-Caltech Research CollaborationCG2016
Natural Sciences and Engineering Research Council of Canada (NSERC)UNSPECIFIED
Issue or Number:4
Classification Code:OCIS codes: (110.0113) Imaging through turbid media; (120.6150) Speckle imaging; (110.7050) Turbid media
PubMed Central ID:PMC5772388
Record Number:CaltechAUTHORS:20170420-082230274
Persistent URL:
Official Citation:Michelle Cua, Edward (Haojiang) Zhou, and Changhuei Yang, "Imaging moving targets through scattering media," Opt. Express 25, 3935-3945 (2017)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76748
Deposited By: Tony Diaz
Deposited On:20 Apr 2017 16:14
Last Modified:20 Nov 2020 23:00

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