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Stepwise Self-Assembly of DNA Tile Lattices Using dsDNA Bridges

Park, Sung Ha and Finkelstein, Gleb and LaBean, Thomas H. (2008) Stepwise Self-Assembly of DNA Tile Lattices Using dsDNA Bridges. Journal of the American Chemical Society, 130 (1). pp. 40-41. ISSN 0002-7863.

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The simple helical motif of double-strand DNA (dsDNA) has typically been judged to be uninteresting for assembly in DNA-based nanotechnology applications. In this letter, we demonstrate construction of superstructures consisting of heterogeneous DNA motifs using dsDNA in conjunction with more complex, cross-tile building blocks. Incorporation of dsDNA bridges in stepwise assembly processes can be used for controlling length and directionality of superstructures and is analogous to the “reprogramming” of sticky-ends displayed on the DNA tiles. Two distinct self-assembled DNA lattices, fixed-size nanoarrays, and extended 2D crystals of nanotracks with nanobridges, are constructed and visualized by high-resolution, liquid-phase atomic force microscopy.

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Additional Information:© 2008 American Chemical Society. Received October 23, 2007. Publication Date (Web): December 12, 2007. This work has been supported by Grants CCF-0650083, BES-0609288, CCR-0326157, and EIA-0218376 from the National Science Foundation and Grant W911NF-05-1-0466 from the Army Research Office. We thank Prof. Jie Liu for providing access to a DI Veeco Nanoscope IIIa AFM.
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Army Research Office (ARO)W911NF-05-1-0466
Issue or Number:1
Record Number:CaltechAUTHORS:20170420-131101677
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Official Citation:Stepwise Self-Assembly of DNA Tile Lattices Using dsDNA Bridges Sung Ha Park, Gleb Finkelstein, and Thomas H. LaBean Journal of the American Chemical Society 2008 130 (1), 40-41 DOI: 10.1021/ja078122f
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76779
Deposited By: Tony Diaz
Deposited On:20 Apr 2017 20:20
Last Modified:03 Oct 2019 17:49

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