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Cell-transforming ability of a temperature-sensitive mutant of polyoma virus

Fried, Michael (1965) Cell-transforming ability of a temperature-sensitive mutant of polyoma virus. Proceedings of the National Academy of Sciences of the United States of America, 53 (3). pp. 486-491. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:FRIpnas65

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Abstract

Conditional lethal mutants have been shown to be extremely useful in the study of the physiology of viral reproduction and maturation.(1, 2) Since such mutants are distributed over most of the genetic map,(1, 2) they could prove to be valuable in the study of tumor viruses. They may be used to "tag" almost all of the viral genes, a property of obvious physiological and genetical implication; they can also be useful for studying the mechanisms by which these viruses transform normal cells into cancer cells.


Item Type:Article
Additional Information:© 1965 by the National Academy of Sciences. Communicated by Renato Dulbecco, January 18, 1965. The author wishes to thank Professor Renato Dulbecco and Dr. Marguerite Vogt for their advice, encouragement, and stimulation in the pursuit of this work, and also for their many helpful discussions and suggestions in the preparation of this paper. This work was supported in part by a grant (112) from The Nutrition Foundation, and was aided by a USPHS graduate training grant (5T1 GM86).
Issue or Number:3
Record Number:CaltechAUTHORS:FRIpnas65
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:FRIpnas65
Alternative URL:http://dx.doi.org/10.1073/pnas.53.3.486
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:7678
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Mar 2007
Last Modified:14 Nov 2014 19:19

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