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Dorsal Gradient Networks in the Drosophila Embryo

Stathopoulos, Angelike and Levine, Michael (2002) Dorsal Gradient Networks in the Drosophila Embryo. Developmental Biology, 246 (1). pp. 57-67. ISSN 0012-1606. doi:10.1006/dbio.2002.0652. https://resolver.caltech.edu/CaltechAUTHORS:20170424-125011442

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Abstract

Here, we describe one of the major maternal regulatory gradients, Dorsal, and threshold outputs of gene expression that result from the graded distribution of this transcription factor. The analysis of a large number of authentic and synthetic target genes suggests that the Dorsal gradient directly specifies at least four, and possibly as many as seven, different thresholds of gene activity and tissue differentiation. These thresholds initiate the differentiation of the three primary embryonic tissues: the mesoderm, neurogenic ectoderm, and dorsal ectoderm. Moreover, primary readouts of the Dorsal gradient create asymmetries that subdivide each tissue into multiple cell types during gastrulation. Dorsal patterning thresholds represent the culmination of one of the most complete gene regulation network known in development, which begins with the asymmetric positioning of the oocyte nucleus within the egg chamber and leads to the localized activation of the Toll-Dorsal signaling pathway in ventral regions of the early embryo.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1006/dbio.2002.0652DOIArticle
http://www.sciencedirect.com/science/article/pii/S0012160602906524?via%3DihubPublisherArticle
ORCID:
AuthorORCID
Stathopoulos, Angelike0000-0001-6597-2036
Additional Information:© 2002 Elsevier Science. Received 1 March 2002, Revised 8 March 2002, Accepted 8 March 2002, Available online 25 May 2002. We thank members of the Levine lab for helpful discussions, and John Cowden for providing the sim staining depicted in Fig. 4. This work was funded by a grant from the NIH (GM46638) to M.L. A.S. is supported by a postdoctoral fellowship from the NIH (GM20352).
Funders:
Funding AgencyGrant Number
NIHGM46638
NIHGM20352
Subject Keywords:Dorsal; gradient; Drosophila embryo; gene network
Issue or Number:1
DOI:10.1006/dbio.2002.0652
Record Number:CaltechAUTHORS:20170424-125011442
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170424-125011442
Official Citation:Angelike Stathopoulos, Michael Levine, Dorsal Gradient Networks in the Drosophila Embryo, Developmental Biology, Volume 246, Issue 1, 2002, Pages 57-67, ISSN 0012-1606, http://dx.doi.org/10.1006/dbio.2002.0652. (http://www.sciencedirect.com/science/article/pii/S0012160602906524)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76857
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Apr 2017 19:59
Last Modified:15 Nov 2021 17:03

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