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Genomic Regulatory Networks and Animal Development

Stathopoulos, Angelike and Levine, Michael (2005) Genomic Regulatory Networks and Animal Development. Developmental Cell, 9 (4). pp. 449-462. ISSN 1534-5807. doi:10.1016/j.devcel.2005.09.005.

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The synthesis of gene expression data and cis-regulatory analysis permits the elucidation of genomic regulatory networks. These networks provide a direct visualization of the functional interconnections among the regulatory genes and signaling components leading to cell-specific patterns of gene activity. Complex developmental processes are thereby illuminated in ways not revealed by the conventional analysis of individual genes. In this review, we describe emerging networks in several different model systems, and compare them with the gene regulatory network that controls dorsoventral patterning of the Drosophila embryo.

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Stathopoulos, Angelike0000-0001-6597-2036
Additional Information:© 2005 Elsevier Inc. Available online 3 October 2005. We are grateful to Robert Zinzen and Desirea Mecenas for providing pictures of embryos and sharing unpublished results. We also thank William Longabaugh and Dmitri Papatsenko for help with the circuit diagrams, and Eric Davidson, Anna Di Gregorio, and Paul Sternberg for helpful discussions. This work was funded by a grant from the NIH (GM46638) to M.L. and startup funds from Caltech to A.S.
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Issue or Number:4
Record Number:CaltechAUTHORS:20170424-130414231
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Official Citation:Angelike Stathopoulos, Michael Levine, Genomic Regulatory Networks and Animal Development, Developmental Cell, Volume 9, Issue 4, October 2005, Pages 449-462, ISSN 1534-5807, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76861
Deposited By: Tony Diaz
Deposited On:24 Apr 2017 20:36
Last Modified:15 Nov 2021 17:03

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