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Resonance Induced Impedance Sensing of Human Blood Cells

Zheng, Siyang and Nandra, Mandheerej S. and Shih, Victor and Li, Wei and Tai, Yu-Chong (2007) Resonance Induced Impedance Sensing of Human Blood Cells. In: TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference. IEEE , Piscataway, NJ, pp. 1741-1744. ISBN 1-4244-0841-5.

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A challenging problem in AC impedance sensing of particles (e.g., blood cells in plasma) with micro electrodes is that with the shrinking of electrode surface area the electrode double layer capacitance decreases. Combined with the parallel stray capacitance, the system impedance is dominated by these capacitive components. Hence the sensitivity for particle sensing decreases. In this paper, we propose a new approach to solve the problem. The idea is to use resonant sensing by connecting an external parallel inductor to the system. At the resonant frequency, the capacitive components in the system were nullified by the inductor, leaving the electrolyte and particle impedance to be a major component in the system impedance. We then successfully demonstrated this idea by sensing 5 mum polystyrene beads. More important, this technique was extended to sensing blood cells in diluted human whole blood and leukocyte rich plasma. The measured signal pulse height histogram matched well with known volume distribution of erythrocytes and leukocytes.

Item Type:Book Section
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URLURL TypeDescription
Li, Wei0000-0003-2543-2558
Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2007 IEEE. The authors would like to thank for all the members at Caltech Micromachining Group for their value assistance. This work was supported by the National Space Biomedical Research Institute through NASA NCC 9-58.
Funding AgencyGrant Number
Subject Keywords:Impedance, Resonance, Blood, Differentiation
Record Number:CaltechAUTHORS:20170425-155453924
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Official Citation:S. Zheng, M. S. Nandra, V. Shih, W. Li and Y. C. Tai, "Resonance Induced Impedance Sensing of Human Blood Cells," TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference, Lyon, 2007, pp. 1741-1744. doi: 10.1109/SENSOR.2007.4300489
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76923
Deposited By: Kristin Buxton
Deposited On:26 Apr 2017 01:41
Last Modified:09 Mar 2020 13:19

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