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A Facile Preparation of Imidazolinium Chlorides

Kuhn, Kevin M. and Grubbs, Robert H. (2008) A Facile Preparation of Imidazolinium Chlorides. Organic Letters, 10 (10). pp. 2075-2077. ISSN 1523-7060. PMCID PMC2666923. doi:10.1021/ol800628a.

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A process for the preparation of symmetric and unsymmetric imidazolinium chlorides that involves reaction of a formamidine with dichloroethane and a base (a) is described. This method makes it possible to obtain numerous imidazolinium chlorides under solvent-free reaction conditions and in excellent yields with purification by simple filtration. Alternatively, symmetric imidazolinium chlorides can be prepared directly in moderate yields from substituted anilines by utilizing half of the formamidine intermediate as sacrificial base (b).

Item Type:Article
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URLURL TypeDescription CentralArticle Information
Grubbs, Robert H.0000-0002-0057-7817
Additional Information:© 2008 American Chemical Society. Received 18 March 2008. Published online 16 April 2008. Published in print 1 May 2008. We gratefully acknowledge financial support from NIH Grant No. GM31332 to R.H.G.
Funding AgencyGrant Number
Issue or Number:10
PubMed Central ID:PMC2666923
Record Number:CaltechAUTHORS:20170426-104049362
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Official Citation:A Facile Preparation of Imidazolinium Chlorides Kevin M. Kuhn and Robert H. Grubbs Organic Letters 2008 10 (10), 2075-2077 DOI: 10.1021/ol800628a
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:76947
Deposited By: Ruth Sustaita
Deposited On:26 Apr 2017 18:05
Last Modified:15 Nov 2021 17:04

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