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Electrochemically Programmed, Spatially Selective Biofunctionalization of Silicon Wires

Bunimovich, Yuri L. and Ge, Guanglu and Beverly, Kristen C. and Ries, Ryan S. and Hood, Leroy and Heath, James R. (2004) Electrochemically Programmed, Spatially Selective Biofunctionalization of Silicon Wires. Langmuir, 20 (24). pp. 10630-10638. ISSN 0743-7463. https://resolver.caltech.edu/CaltechAUTHORS:20170427-110128445

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Abstract

A method for the spatially selective biofunctionalization of silicon micro- and nanostructures is reported, and results are presented for both single-crystal silicon (111) or (100) surfaces. An electroactive monolayer of hydroquinone was formed on the surface of H-terminated silicon working electrodes via an olefin reaction with UV-generated surface radicals. Molecules presenting either cyclopentadiene or a thiol group can be immobilized onto the regions where the hydroquinone has been oxidized. Molecular size and crystal orientation are evaluated as important factors that dictate the electrode stability in aqueous solution under anodic potentials. Monolayers composed of smaller molecules on (111) surfaces exhibit the highest packing density and are more effective in preventing anodic oxidation of the underlying substrate. Voltammetry, X-ray photoelectron spectroscopy, and atomic force and fluorescence microscopy are utilized to interrogate the kinetic rates of biofunctionalization, the extent of surface coverage, monolayer quality, and the spatial selectivity of the process.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/la047913hDOIArticle
http://pubs.acs.org/doi/abs/10.1021/la047913hPublisherArticle
ORCID:
AuthorORCID
Hood, Leroy0000-0001-7158-3678
Heath, James R.0000-0001-5356-4385
Additional Information:© 2004 American Chemical Society. Received 21 August 2004. Published online 15 October 2004. Published in print 1 November 2004. We thank Dr. Hsian-Rong Tseng and Dr. C. J. Yu for their assistance with the synthesis and many helpful discussions. We acknowledge support from the DARPA moletronic program and the Institute for Collaborative Biotechnologies through grant DAAD19-03-D-0004 from the U.S. Army Research Office and the Norton Simon Research Foundation.
Funders:
Funding AgencyGrant Number
Army Research Office (ARO)DAAD19-03-D-0004
Norton Simon Research FoundationUNSPECIFIED
Issue or Number:24
Record Number:CaltechAUTHORS:20170427-110128445
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170427-110128445
Official Citation:Electrochemically Programmed, Spatially Selective Biofunctionalization of Silicon Wires Yuri L. Bunimovich, Guanglu Ge, Kristen C. Beverly, Ryan S. Ries, Leroy Hood, and James R. Heath Langmuir 2004 20 (24), 10630-10638 DOI: 10.1021/la047913h
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77003
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:27 Apr 2017 22:15
Last Modified:03 Oct 2019 17:52

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