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Functionalizing iron oxide with genomic DNA: Materials for drug capture

Blumenfeld, Carl and Schulz, Michael D. and Hetts, Steven and Grubbs, Robert H. (2017) Functionalizing iron oxide with genomic DNA: Materials for drug capture. In: 253rd American Chemical Society National Meeting & Exposition, April 2-6, 2017, San Francisco, CA. https://resolver.caltech.edu/CaltechAUTHORS:20170503-152605584

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Abstract

Chemotherapy agents are well known for producing severe side-effects. One approach to mitigating this offtarget damage is to deliver the chemotherapy directly to the tumor via transarterial chemoembolization, or similar procedures, and then sequestering any chemotherapeutic that enters systemic circulation. Materials capable of such drug capture have yet to be fully realized. We report the synthesis of genomic DNAfunctionalized iron oxide nanoparticles, which we used to capture three common chemotherapy agents (doxorubicin, cisplatin, and epirubicin). Drug capture was studied in biol. relevant solns. including phosphate buffered saline, human serum, and porcine whole blood. The efficacy of these nanomaterials indicates that drug capture is a viable strategy for mitigating the harmful side-effects assocd. with chemotherapy.


Item Type:Conference or Workshop Item (Paper)
Related URLs:
URLURL TypeDescription
https://www.acs.org/content/acs/en/meetings/spring-2017.htmlOrganizationConference Website
ORCID:
AuthorORCID
Grubbs, Robert H.0000-0002-0057-7817
Additional Information:© 2017 American Chemical Society.
Record Number:CaltechAUTHORS:20170503-152605584
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170503-152605584
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77174
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:04 May 2017 01:28
Last Modified:03 Oct 2019 17:54

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