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Spectroscopy and Electrochemistry of Ruthenium-Modified Nucleic Acids: Design of a Novel Metal-Binding Nucleoside

Rack, Jeffrey J. and Krider, Elizabeth S. and Meade, Thomas J. (2000) Spectroscopy and Electrochemistry of Ruthenium-Modified Nucleic Acids: Design of a Novel Metal-Binding Nucleoside. Journal of the American Chemical Society, 122 (26). pp. 6287-6288. ISSN 0002-7863. https://resolver.caltech.edu/CaltechAUTHORS:20170510-125715274

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Abstract

Electron transfer (ET) reactions through DNA have been the subject of numerous investigations due to the implications for light-induced DNA damage and the quest for understanding long-range ET events in biological molecules. An important objective in this area continues to be the facile and site-specific incorporation of metal complexes into DNA. While recent work has focused on nucleobasic and nonnucleosidic sites for the attachment of high-potential complexes, our efforts have concentrated on the ribose ring (to minimize structural perturbations) as the incorporation site for both high- and low-potential metal complexes.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja9939643DOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja9939643PublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/ja9939643PublisherSupporting Information
Additional Information:© 2000 American Chemical Society. Received November 10, 1999. Publication Date (Web): June 13, 2000. We wish to thank Jay R. Winkler and Harry B. Gray of the Beckman Institute Laser Resource Center (BILRC) and Graham Heath of the Australian National University for helpful discussions. Mass spectrometry results were provided by Gary Hathaway (Caltech PPMAL). This work was supported by NIST (ATP) Award 70NANB5H1031, Jet Propulsion Laboratory (JPL 67192), and the Beckman Institute Biological Imaging Center.
Funders:
Funding AgencyGrant Number
National Institute of Standards and Technology (NIST)70NANB5H1031
JPL67192
Caltech Beckman InstituteUNSPECIFIED
Issue or Number:26
Record Number:CaltechAUTHORS:20170510-125715274
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170510-125715274
Official Citation:Spectroscopy and Electrochemistry of Ruthenium-Modified Nucleic Acids:  Design of a Novel Metal-Binding Nucleoside Jeffrey J. Rack, Elizabeth S. Krider, and Thomas J. Meade Journal of the American Chemical Society 2000 122 (26), 6287-6288 DOI: 10.1021/ja9939643
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77346
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 May 2017 19:58
Last Modified:03 Oct 2019 17:56

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