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Peptide−Nanowire Hybrid Materials for Selective Sensing of Small Molecules

McAlpine, Michael C. and Agnew, Heather D. and Rohde, Rosemary D. and Blanco, Mario and Ahmad, Habib and Stuparu, Andreea D. and Goddard, William A., III and Heath, James R. (2008) Peptide−Nanowire Hybrid Materials for Selective Sensing of Small Molecules. Journal of the American Chemical Society, 130 (29). pp. 9583-9589. ISSN 0002-7863. PMCID PMC3716463.

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The development of a miniaturized sensing platform for the selective detection of chemical odorants could stimulate exciting scientific and technological opportunities. Oligopeptides are robust substrates for the selective recognition of a variety of chemical and biological species. Likewise, semiconducting nanowires are extremely sensitive gas sensors. Here we explore the possibilities and chemistries of linking peptides to silicon nanowire sensors for the selective detection of small molecules. The silica surface of the nanowires is passivated with peptides using amide coupling chemistry. The peptide/nanowire sensors can be designed, through the peptide sequence, to exhibit orthogonal responses to acetic acid and ammonia vapors, and can detect traces of these gases from “chemically camouflaged” mixtures. Through both theory and experiment, we find that this sensing selectivity arises from both acid/base reactivity and from molecular structure. These results provide a model platform for what can be achieved in terms of selective and sensitive “electronic noses.”

Item Type:Article
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URLURL TypeDescription Information CentralArticle
Goddard, William A., III0000-0003-0097-5716
Heath, James R.0000-0001-5356-4385
Additional Information:© 2008 American Chemical Society. Received April 5, 2008. Publication Date (Web): June 25, 2008. We thank S. Millward, W. Dichtel, and W. S. Yeo for useful discussions. The XPS measurements were carried out at the Molecular Materials Research Center of the Beckman Institute at Caltech. Peptide purification by HPLC was performed in the Beckman Institute Laser Resource Center at Caltech. M.C.M. thanks the Intelligence Community Postdoctoral Research Fellowship Program for financial support. H.D.A. thanks the National Science Foundation Graduate Research Fellowship Program for financial support. R.D.R. thanks the Gates Millennium Scholars Program for financial support. J.R.H. acknowledges primary support of this work via a contract from the MITRE Corporation, and support from the National Cancer Institute (#5U54 CA119347).
Funding AgencyGrant Number
Intelligence Community Postdoctoral Research Fellowship ProgramUNSPECIFIED
NSF Graduate Research FellowshipUNSPECIFIED
Bill and Melinda Gates FoundationUNSPECIFIED
NIH5U54 CA119347
National Cancer InstituteUNSPECIFIED
Issue or Number:29
PubMed Central ID:PMC3716463
Record Number:CaltechAUTHORS:20170512-112704937
Persistent URL:
Official Citation:Peptide−Nanowire Hybrid Materials for Selective Sensing of Small Molecules Michael C. McAlpine, Heather D. Agnew, Rosemary D. Rohde, Mario Blanco, Habib Ahmad, Andreea D. Stuparu, William A. Goddard, III, and James R. Heath Journal of the American Chemical Society 2008 130 (29), 9583-9589 DOI: 10.1021/ja802506d
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77410
Deposited By: Tony Diaz
Deposited On:12 May 2017 23:33
Last Modified:03 Oct 2019 17:57

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