He, Qing and Pang, Changlin and Tai, Yu-Chong and Lee, Terry D. (2004) Ion liquid chromatography on-a-chip with beads-packed parylene column. In: 17th IEEE International Conference on Micro Electro Mechanical Systems. Maastricht MEMS 2004 Technical Digest. IEEE , Piscataway, NJ, pp. 212-215. ISBN 0-7803-8265-X. https://resolver.caltech.edu/CaltechAUTHORS:20170518-120228304
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Abstract
A parylene-MEMS ion-exchange Liquid Chromatography (LC) chip is presented here. The chip is integrated with microfluidic I/O ports, a separation column, frits/filters, and a conductivity detector. The column is packed with conventional LC stationary phase support materials, i.e. micro-beads with surface functional groups. To withstand high pressure normally encountered in high performance liquid chromatography (HPLC), a self-aligned, channel-anchoring technique is developed to increase the pressure rating of the parylene microfluidic devices from 30 to at least 800psi. On-chip injection, separation and detection of anions in water, with ~25 ppm concentration, have been successfully demonstrated. To our knowledge, this is the first demonstration of microbeads-packed column ion liquid Chromatography (LC) on a chip.
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| Additional Information: | © 2004 IEEE. This work is supported by the NSF CENS Center (CCR-0121778), NSF ERC Center at Caltech (EEC-9402726) and NIH (R01 RR06217). | ||||||||||
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| DOI: | 10.1109/MEMS.2004.1290560 | ||||||||||
| Record Number: | CaltechAUTHORS:20170518-120228304 | ||||||||||
| Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20170518-120228304 | ||||||||||
| Official Citation: | Qing He, Changlin Pang, Yu-Chong Tai and T. D. Lee, "Ion liquid chromatography on-a-chip with beads-packed parylene column," 17th IEEE International Conference on Micro Electro Mechanical Systems. Maastricht MEMS 2004 Technical Digest, 2004, pp. 212-215. doi: 10.1109/MEMS.2004.1290560 | ||||||||||
| Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||||||
| ID Code: | 77575 | ||||||||||
| Collection: | CaltechAUTHORS | ||||||||||
| Deposited By: | INVALID USER | ||||||||||
| Deposited On: | 18 May 2017 19:11 | ||||||||||
| Last Modified: | 15 Nov 2021 17:32 |
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