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Electrolysis-based on-chip dispensing system for ESI-MS

Xie, Jun and He, Qing and Tai, Yu-Chong and Liu, Jun and Lee, Terry (2003) Electrolysis-based on-chip dispensing system for ESI-MS. In: The Sixteenth Annual International Conference on Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE , Piscataway, NJ, pp. 443-446. ISBN 0-7803-7744-3.

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We report here an integrated on-chip sample dispensing system for Electrospray Ionization-Mass Spectrometry (ESI-MS) applications. The stand-alone chip includes an electrolysis-based micropump, a passive micro mixer and an ESI nozzle. Operation of the chip doesn't require any external fluidic coupling because the chip is designed to have samples filled, sealed and stored in reservoirs inside the chip before testing. Demonstrated here is a chip with two sample reservoirs and dispensing of the samples is electrically controlled individually. Experimentally, on-chip co-dispensing of two different samples is successfully achieved with a dispensing flow rate about 50 nl/min and a continuous spray for 2 minutes.

Item Type:Book Section
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Tai, Yu-Chong0000-0001-8529-106X
Additional Information:© 2003 IEEE. This work is supported in part by NSF (Grant No. EEC-9402726) and NIH (Grant No. 5R01 RR06217-10). The authors would like to thank Mr. Trevor Roper for the assistance with fabrication.
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NIH5R01 RR06217-10
Record Number:CaltechAUTHORS:20170518-130836747
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Official Citation:Jun Xie, Qing He, Yu-Chong Tai, Jun Liu and T. Lee, "Electrolysis-based on-chip dispensing system for ESI-MS," The Sixteenth Annual International Conference on Micro Electro Mechanical Systems, 2003. MEMS-03 Kyoto. IEEE, 2003, pp. 443-446. doi: 10.1109/MEMSYS.2003.1189781
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77582
Deposited On:18 May 2017 21:24
Last Modified:15 Nov 2021 17:32

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