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Neural immunoglobulin superfamily interaction networks

Zinn, Kai and Özkan, Engin (2017) Neural immunoglobulin superfamily interaction networks. Current Opinion in Neurobiology, 45 . pp. 99-105. ISSN 0959-4388. PMCID PMC5554755.

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The immunoglobulin superfamily (IgSF) encompasses hundreds of cell surface proteins containing multiple immunoglobulin-like (Ig) domains. Among these are neural IgCAMs, which are cell adhesion molecules that mediate interactions between cells in the nervous system. IgCAMs in some vertebrate IgSF subfamilies bind to each other homophilically and heterophilically, forming small interaction networks. In Drosophila, a global ‘interactome’ screen identified two larger networks in which proteins in one IgSF subfamily selectively interact with proteins in a different subfamily. One of these networks, the ‘Dpr-ome’, includes 30 IgSF proteins, each of which is expressed in a unique subset of neurons. Recent evidence shows that one interacting protein pair within the Dpr-ome network is required for development of the brain and neuromuscular system.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Zinn, Kai0000-0002-6706-5605
Özkan, Engin0000-0002-0263-6729
Additional Information:© 2017 Elsevier Ltd. Available online 27 May 2017. We thank Christopher Garcia, Robert Carrillo and Kaushiki Menon for discussions and R.C. and K.M. for images in Figure 2. Work in the Zinn group was supported by National Institutes of Health (NIH) grants R37 NS28182 and U01 MH109147. Work in the Özkan group was supported by NIH RO1 NS097161.
Funding AgencyGrant Number
NIHR37 NS28182
NIHU01 MH109147
NIHRO1 NS097161
PubMed Central ID:PMC5554755
Record Number:CaltechAUTHORS:20170530-155301800
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Official Citation:Kai Zinn, Engin Özkan, Neural immunoglobulin superfamily interaction networks, Current Opinion in Neurobiology, Volume 45, August 2017, Pages 99-105, ISSN 0959-4388, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77839
Deposited By: Tony Diaz
Deposited On:30 May 2017 23:02
Last Modified:15 Sep 2017 04:47

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