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Dry coupling for whole-body small-animal photoacoustic computed tomography

Yeh, Chenghung and Li, Lei and Zhu, Liren and Xia, Jun and Li, Chiye and Chen, Wanyi and Garcia-Uribe, Alejandro and Maslov, Konstantin I. and Wang, Lihong V. (2017) Dry coupling for whole-body small-animal photoacoustic computed tomography. Journal of Biomedical Optics, 22 (4). Art. No. 041017. ISSN 1083-3668. PMCID PMC5995148. https://resolver.caltech.edu/CaltechAUTHORS:20170602-071608181

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Abstract

We have enhanced photoacoustic computed tomography with dry acoustic coupling that eliminates water immersion anxiety and wrinkling of the animal and facilitates incorporating complementary modalities and procedures. The dry acoustic coupler is made of a tubular elastic membrane enclosed by a closed transparent water tank. The tubular membrane ensures water-free contact with the animal, and the closed water tank allows pressurization for animal stabilization. The dry coupler was tested using a whole-body small-animal ring-shaped photoacoustic computed tomography system. Dry coupling was found to provide image quality comparable to that of conventional water coupling.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.22.4.041017DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995148/PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE). Paper 160544SSR received Aug. 10, 2016; accepted for publication Feb. 8, 2017; published online Feb. 23, 2017. The authors appreciate the close reading of the manuscript by Prof. James Ballard. We also thank Chin Ting, Junjie Yao, Jinyang Liang, and Yong Zhou for helpful discussions. This work was sponsored by the National Institutes of Health Grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 CA186567 (NIH Director’s Transformative Research Award), and R01 EB016963.
Funders:
Funding AgencyGrant Number
NIHDP1 EB016986
NIHR01 CA186567
NIHR01 EB016963
Subject Keywords:dry coupling; water immersion; whole-body small-animal imaging; photoacoustic computed tomography
Issue or Number:4
PubMed Central ID:PMC5995148
Record Number:CaltechAUTHORS:20170602-071608181
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170602-071608181
Official Citation:Yeh C, Li L, Zhu L, et al; Dry coupling for whole-body small-animal photoacoustic computed tomography. J. Biomed. Opt. 0001;22(4):041017. doi:10.1117/1.JBO.22.4.041017.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:77905
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:02 Jun 2017 18:29
Last Modified:03 Oct 2019 18:03

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