A Caltech Library Service

Whipworm kinomes reflect a unique biology and adaptation to the host animal

Stroehlein, Andreas J. and Young, Neil D. and Korhonen, Pasi K. and Chang, Bill C. H. and Nejsum, Peter and Pozio, Edoardo and La Rosa, Giuseppe and Sternberg, Paul W. and Gasser, Robin B. (2017) Whipworm kinomes reflect a unique biology and adaptation to the host animal. International Journal for Parasitology, 47 (13). pp. 857-866. ISSN 0020-7519.

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item:


Roundworms belong to a diverse phylum (Nematoda) which is comprised of many parasitic species including whipworms (genus Trichuris). These worms have adapted to a biological niche within the host and exhibit unique morphological characteristics compared with other nematodes. Although these adaptations are known, the underlying molecular mechanisms remain elusive. The availability of genomes and transcriptomes of some whipworms now enables detailed studies of their molecular biology. Here, we defined and curated the full complement of an important class of enzymes, the protein kinases (kinomes) of two species of Trichuris, using an advanced and integrated bioinformatic pipeline. We investigated the transcription of Trichuris suis kinase genes across developmental stages, sexes and tissues, and reveal that selectively transcribed genes can be linked to central roles in developmental and reproductive processes. We also classified and functionally annotated the curated kinomes by integrating evidence from structural modelling and pathway analyses, and compared them with other curated kinomes of phylogenetically diverse nematode species. Our findings suggest unique adaptations in signalling processes governing worm morphology and biology, and provide an important resource that should facilitate experimental investigations of kinases and the biology of signalling pathways in nematodes.

Item Type:Article
Related URLs:
URLURL TypeDescription
Sternberg, Paul W.0000-0002-7699-0173
Additional Information:© 2017 Australian Society for Parasitology. Published by Elsevier Ltd. Received 21 February 2017, Revised 14 April 2017, Accepted 20 April 2017, Available online 10 June 2017.
Subject Keywords:Kinome; Gene curation; Nematodes; Kinase signalling; Host–parasite interactions
Issue or Number:13
Record Number:CaltechAUTHORS:20170619-081556369
Persistent URL:
Official Citation:Andreas J. Stroehlein, Neil D. Young, Pasi K. Korhonen, Bill C.H. Chang, Peter Nejsum, Edoardo Pozio, Giuseppe La Rosa, Paul W. Sternberg, Robin B. Gasser, Whipworm kinomes reflect a unique biology and adaptation to the host animal, In International Journal for Parasitology, Volume 47, Issue 13, 2017, Pages 857-866, ISSN 0020-7519, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78318
Deposited By: Tony Diaz
Deposited On:19 Jun 2017 16:14
Last Modified:03 Oct 2019 18:07

Repository Staff Only: item control page