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The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

Yoo, Bryan B. and Mazmanian, Sarkis K. (2017) The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut. Immunity, 46 (6). pp. 910-926. ISSN 1074-7613. PMCID PMC5551410. doi:10.1016/j.immuni.2017.05.011.

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Interactions between the nervous and immune systems enable the gut to respond to the variety of dietary products that it absorbs, the broad spectrum of pathogens that it encounters, and the diverse microbiome that it harbors. The enteric nervous system (ENS) senses and reacts to the dynamic ecosystem of the gastrointestinal (GI) tract by translating chemical cues from the environment into neuronal impulses that propagate throughout the gut and into other organs in the body, including the central nervous system (CNS). This review will describe the current understanding of the anatomy and physiology of the GI tract by focusing on the ENS and the mucosal immune system. We highlight emerging literature that the ENS is essential for important aspects of microbe-induced immune responses in the gut. Although most basic and applied research in neuroscience has focused on the brain, the proximity of the ENS to the immune system and its interface with the external environment suggest that novel paradigms for nervous system function await discovery.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Yoo, Bryan B.0000-0003-1450-2696
Mazmanian, Sarkis K.0000-0003-2713-1513
Additional Information:© 2017 Elsevier Inc. Available online 20 June 2017. We thank Gregory Donaldson and Drs. Timothy Sampson and Hiutung Chu for critical reading of this manuscript. B.B.Y. is supported by an NIH xTrain Predoctoral Training grant (5T32GM007616-38). Related research in the Mazmanian laboratory is funded by grants from the NIH (MH100556, DK078938, and NS085910), the Defense Advanced Research Projects Agency, the Heritage Medical Research Institute, and the Simons Foundation.
Group:Heritage Medical Research Institute
Funding AgencyGrant Number
NIH Predoctoral Fellowship5T32GM007616-38
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Heritage Medical Research InstituteUNSPECIFIED
Simons FoundationUNSPECIFIED
Subject Keywords:intestinal microbiota; enteric nervous system; gut-brain axis; neuro-immune interactions; gastrointestinal tract; neuro-immunity
Issue or Number:6
PubMed Central ID:PMC5551410
Record Number:CaltechAUTHORS:20170622-103637222
Persistent URL:
Official Citation:Bryan B. Yoo, Sarkis K. Mazmanian, The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut, Immunity, Volume 46, Issue 6, 20 June 2017, Pages 910-926, ISSN 1074-7613,
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78465
Deposited By: Tony Diaz
Deposited On:22 Jun 2017 17:43
Last Modified:25 Mar 2022 17:55

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