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How a lncRNA Shapes Chromatin Structure to Control Gene Expression

Guttman, Mitchell (2017) How a lncRNA Shapes Chromatin Structure to Control Gene Expression. Biophysical Journal, 112 (3, Supp. 1). 158a. ISSN 0006-3495.

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Mammalian genomes encode many thousands of long non-coding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and specifically within the chromatin-associated fraction. Here, we will discuss the evidence that many nuclear-retained lncRNAs can interact with various chromatin regulatory proteins and recruit them to specific sites on DNA to regulate gene expression and shape three-dimensional nuclear organization. Specifically, we will discuss emerging mechanistic insights derived from the Xist lncRNA, a paradigm for lncRNA-mediated gene regulation, into how lncRNAs regulate gene expression by localizing to genomic target sites, recruiting regulatory complexes, and reshaping nuclear organization.

Item Type:Article
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Guttman, Mitchell0000-0003-4748-9352
Additional Information:© 2017 Elsevier B.V. Available online 3 February 2017. Meeting Abstract: 779-Symp.
Issue or Number:3, Supp. 1
Record Number:CaltechAUTHORS:20170623-103451742
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Official Citation:Mitchell Guttman, How a lncRNA Shapes Chromatin Structure to Control Gene Expression, Biophysical Journal, Volume 112, Issue 3, Supplement 1, 3 February 2017, Page 158a, ISSN 0006-3495, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78513
Deposited By: Tony Diaz
Deposited On:24 Jun 2017 03:03
Last Modified:03 Oct 2019 18:09

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