CaltechAUTHORS
  A Caltech Library Service

How a lncRNA Shapes Chromatin Structure to Control Gene Expression

Guttman, Mitchell (2017) How a lncRNA Shapes Chromatin Structure to Control Gene Expression. Biophysical Journal, 112 (3, Supp. 1). 158a. ISSN 0006-3495. https://resolver.caltech.edu/CaltechAUTHORS:20170623-103451742

Full text is not posted in this repository. Consult Related URLs below.

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20170623-103451742

Abstract

Mammalian genomes encode many thousands of long non-coding RNAs (lncRNAs) that play important roles in diverse biological processes. As a class, lncRNAs are generally enriched in the nucleus and specifically within the chromatin-associated fraction. Here, we will discuss the evidence that many nuclear-retained lncRNAs can interact with various chromatin regulatory proteins and recruit them to specific sites on DNA to regulate gene expression and shape three-dimensional nuclear organization. Specifically, we will discuss emerging mechanistic insights derived from the Xist lncRNA, a paradigm for lncRNA-mediated gene regulation, into how lncRNAs regulate gene expression by localizing to genomic target sites, recruiting regulatory complexes, and reshaping nuclear organization.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.bpj.2016.11.868DOIArticle
http://www.sciencedirect.com/science/article/pii/S0006349516318987PublisherArticle
ORCID:
AuthorORCID
Guttman, Mitchell0000-0003-4748-9352
Additional Information:© 2017 Elsevier B.V. Available online 3 February 2017. Meeting Abstract: 779-Symp.
Issue or Number:3, Supp. 1
Record Number:CaltechAUTHORS:20170623-103451742
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170623-103451742
Official Citation:Mitchell Guttman, How a lncRNA Shapes Chromatin Structure to Control Gene Expression, Biophysical Journal, Volume 112, Issue 3, Supplement 1, 3 February 2017, Page 158a, ISSN 0006-3495, https://doi.org/10.1016/j.bpj.2016.11.868. (http://www.sciencedirect.com/science/article/pii/S0006349516318987)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78513
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:24 Jun 2017 03:03
Last Modified:03 Oct 2019 18:09

Repository Staff Only: item control page