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Control of Mitochondrial Function by Fusion and Fission

Chen, Hsiuchen and Chan, David (2017) Control of Mitochondrial Function by Fusion and Fission. Biophysical Journal, 112 (3, Supp. 1). 179a. ISSN 0006-3495. doi:10.1016/j.bpj.2016.11.994.

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Several neurodegenerative diseases are associated with defects in mitochondrial fusion or fission, which are opposing processes that regulate mitochondrial function. This observation raises the issue of whether a defect in one process can be alleviated by simultaneously reducing the opposing process. We used mouse models to address this issue. Mff is a mitochondrial outer membrane protein important for mitochondrial fission. We generated Mff mutant mice and found that they die at 13 weeks due to heart failure caused by dilated cardiomyopathy. Mff cardiac tissue shows reduced mitochondrial density, reduced respiratory chain activity, and increased mitophagy. Mfn1 deficient mice die shortly after birth. However, mice with loss of both Mff and Mfn1 have normal heart function, lifespan and respiratory chain function. The reciprocal rescue with both mutations indicate that retuning mitochondrial dynamics can restore tissue integrity and mitochondrial physiology at the whole organ level.

Item Type:Article
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Chan, David0000-0002-0191-2154
Additional Information:© 2017 Elsevier B.V. Available online 3 February 2017. Meeting Abstract: 886-Symp.
Issue or Number:3, Supp. 1
Record Number:CaltechAUTHORS:20170623-104426059
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Official Citation:Hsiuchen Chen, David Chan, Control of Mitochondrial Function by Fusion and Fission, Biophysical Journal, Volume 112, Issue 3, Supplement 1, 3 February 2017, Page 179a, ISSN 0006-3495, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78515
Deposited By: Tony Diaz
Deposited On:23 Jun 2017 19:47
Last Modified:15 Nov 2021 17:40

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