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The elastic transfer model of angular rate modulation in F_1-ATPase stalling and controlled rotation experiments

Volkán-Kacsó, S. (2017) The elastic transfer model of angular rate modulation in F_1-ATPase stalling and controlled rotation experiments. Modern Physics Letters B, 31 (17). Art. No. 1730002. ISSN 0217-9849.

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The recent experimental, theoretical and computational advances in the field of F_1-ATPase single-molecule microscopy are briefly surveyed. The role of theory is revealed in the statistical analysis, interpretation and prediction of single-molecule experimental trajectories, and in linking them with atomistic simulations. In particular, a theoretical model of elastically coupled molecular group transfer is reviewed and a detailed method for its application in stalling and controlled rotation experiments is provided. It is shown how the model can predict, using previous experiments, the rates of ligand binding/release processes (steps) and their exponential dependence on rotor angle in these experiments. The concept of Brønsted slopes is reviewed in the context of the single-molecule experiments, and the rate versus rotor angle relations are explained using the elastic model. These experimental data are treated in terms of the effect of thermodynamic driving forces on the rates assuming that the rotor shaft is elastically coupled to stator ring subunits in which the steps occur. In the application of the group transfer model on an extended angular range processes leading up to the transfer are discussed. Implications for large-scale atomistic simulation are suggested for the treatment of torque-generating steps.

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Additional Information:© 2017 World Scientific Publishing Co Pte Ltd. Received: 10 February 2017; Revised: 12 May 2017; Accepted: 29 May 2017; Published: 14 June 2017.
Subject Keywords:F-ATPase; biomolecular motors; ring NTPase; single-molecule imaging; molecular transfer theory
Issue or Number:17
Record Number:CaltechAUTHORS:20170627-073718440
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Official Citation:The elastic transfer model of angular rate modulation in F1-ATPase stalling and controlled rotation experiments S. Volkán-Kacsó Modern Physics Letters B 2017 31:17
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78587
Deposited By: Tony Diaz
Deposited On:27 Jun 2017 19:53
Last Modified:03 Oct 2019 18:09

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