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Design and Evolution of Enzymes for Non-natural Chemistry

Hammer, Stephan C. and Knight, Anders M. and Arnold, Frances H. (2017) Design and Evolution of Enzymes for Non-natural Chemistry. Current Opinion in Green and Sustainable Chemistry, 7 . pp. 23-30. ISSN 2452-2236. https://resolver.caltech.edu/CaltechAUTHORS:20170628-110616752

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Abstract

Enzymes are used in biocatalytic processes for the efficient and sustainable production of pharmaceuticals, fragrances, fine chemicals, and other products. Most bioprocesses exploit chemistry found in nature, but we are now entering a realm of biocatalysis that goes well beyond. Enzymes have been engineered to catalyze reactions previously only accessible with synthetic catalysts. Because they can be tuned by directed evolution, many of these new biocatalysts have been shown to perform abiological reactions with high activity and selectivity. We discuss recent examples, showcase catalyst improvements achieved using directed evolution, and comment on some current and future implications of non-natural enzyme evolution for sustainable chemical synthesis.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.cogsc.2017.06.002DOIArticle
http://www.sciencedirect.com/science/article/pii/S2452223617300354PublisherArticle
ORCID:
AuthorORCID
Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2017 Elsevier B.V. Received 27 April 2017, Revised 22 May 2017, Accepted 7 June 2017, Available online 10 June 2017.
Group:Rosen Bioengineering Center
Subject Keywords:Biocatalysis; Directed Evolution; Sustainable Chemistry; Synthetic Biology; Protein Engineering
Record Number:CaltechAUTHORS:20170628-110616752
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170628-110616752
Official Citation:Stephan C. Hammer, Anders M. Knight, Frances H. Arnold, Design and evolution of enzymes for non-natural chemistry, Current Opinion in Green and Sustainable Chemistry, Volume 7, 2017, Pages 23-30, ISSN 2452-2236, http://dx.doi.org/10.1016/j.cogsc.2017.06.002. (http://www.sciencedirect.com/science/article/pii/S2452223617300354)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78649
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Jun 2017 18:10
Last Modified:03 Oct 2019 18:10

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