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Regulatory states in the developmental control of gene expression

Peter, Isabelle S. (2017) Regulatory states in the developmental control of gene expression. Briefings in Functional Genomics, 16 (5). pp. 281-287. ISSN 2041-2649. PMCID PMC5860005. doi:10.1093/bfgp/elx009. https://resolver.caltech.edu/CaltechAUTHORS:20170629-151929097

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Abstract

A growing body of evidence shows that gene expression in multicellular organisms is controlled by the combinatorial function of multiple transcription factors. This indicates that not the individual transcription factors or signaling molecules, but the combination of expressed regulatory molecules, the regulatory state, should be viewed as the functional unit in gene regulation. Here, I discuss the concept of the regulatory state and its proposed role in the genome-wide control of gene expression. Recent analyses of regulatory gene expression in sea urchin embryos have been instrumental for solving the genomic control of cell fate specification in this system. Some of the approaches that were used to determine the expression of regulatory states during sea urchin embryogenesis are reviewed. Significant developmental changes in regulatory state expression leading to the distinct specification of cell fates are regulated by gene regulatory network circuits. How these regulatory state transitions are encoded in the genome is illuminated using the sea urchin endoderm–mesoderms cell fate decision circuit as an example. These observations highlight the importance of considering developmental gene regulation, and the function of individual transcription factors, in the context of regulatory states.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1093/bfgp/elx009DOIArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860005PubMed CentralArticle
ORCID:
AuthorORCID
Peter, Isabelle S.0000-0003-3685-3147
Additional Information:© 2017 The Author. Published by Oxford University Press. Published: 24 April 2017. I wish to thank Deanna Thomas for her work in preparing the figures and Jonathan Valencia for providing the image showing gcm expression in the late embryo. I am deeply grateful to Eric Davidson for countless discussions over the years that contributed to the thoughts expressed here. This work was supported by National Institutes of Health Grant HD-037105.
Funders:
Funding AgencyGrant Number
NIHHD-037105
Subject Keywords:regulatory state, gene regulatory networks, sea urchin development, gene regulation
Issue or Number:5
PubMed Central ID:PMC5860005
DOI:10.1093/bfgp/elx009
Record Number:CaltechAUTHORS:20170629-151929097
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170629-151929097
Official Citation:Isabelle S. Peter; Regulatory states in the developmental control of gene expression, Briefings in Functional Genomics, Volume 16, Issue 5, 1 September 2017, Pages 281–287, https://doi.org/10.1093/bfgp/elx009
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78714
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:30 Jun 2017 16:56
Last Modified:15 Nov 2021 17:42

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