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Good night, sleep tight: The effects of sleep deprivation on spatial associative learning in zebrafish

Pinheiro-da-Silva, Jaquelinne and Tran, Steven and Silva, Priscila Fernandes and Luchiari, Ana Carolina (2017) Good night, sleep tight: The effects of sleep deprivation on spatial associative learning in zebrafish. Pharmacology Biochemistry and Behavior, 159 . pp. 36-47. ISSN 0091-3057. https://resolver.caltech.edu/CaltechAUTHORS:20170705-082818680

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Abstract

Learning and memory are vital to an animal's survival, and numerous factors can disrupt cognitive performance. Sleep is an evolutionarily conserved physiological process known to be important for the consolidation of learning and memory. The zebrafish has emerged as a powerful model organism sharing organizational and functional characteristics with other vertebrates, providing great translational relevance. In our study, we used a simple spatial associative learning task to quantify the effects of sleep deprivation (partial vs. total) on learning performance in zebrafish, using an animated conspecific shoal image as a reward. Control animals maintained on a regular light:dark cycle were able to acquire the association between the unconditioned and conditioned stimulus, reinforcing zebrafish as a valid and reliable model for appetitive conditioning tasks. Notably, sleep deprivation did not alter the perception of and response to the conspecific image. In contrast, although partial sleep deprivation did not impair cognitive performance, total sleep deprivation significantly impaired performance on the associative learning task. Our results suggest that sleep is important for learning and memory, and that the effects of sleep deprivation on these processes can be investigated in zebrafish.


Item Type:Article
Related URLs:
URLURL TypeDescription
https://doi.org/10.1016/j.pbb.2017.06.011DOIArticle
http://www.sciencedirect.com/science/article/pii/S0091305716303148PublisherArticle
Additional Information:© 2017 Elsevier Inc. Received 16 December 2016, Revised 16 June 2017, Accepted 20 June 2017, Available online 23 June 2017.
Subject Keywords:Learning; Memory; Associative learning task; Sleep; Social reward
Record Number:CaltechAUTHORS:20170705-082818680
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170705-082818680
Official Citation:Jaquelinne Pinheiro-da-Silva, Steven Tran, Priscila Fernandes Silva, Ana Carolina Luchiari, Good night, sleep tight: The effects of sleep deprivation on spatial associative learning in zebrafish, Pharmacology Biochemistry and Behavior, Volume 159, 2017, Pages 36-47, ISSN 0091-3057, http://dx.doi.org/10.1016/j.pbb.2017.06.011. (http://www.sciencedirect.com/science/article/pii/S0091305716303148)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78748
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2017 21:57
Last Modified:03 Oct 2019 18:11

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