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Considerations for Infectious Disease Research Studies Using Animals

Colby, Lesley A. and Quenee, Lauriane E. and Zitzow, Lois A. (2017) Considerations for Infectious Disease Research Studies Using Animals. Comparative Medicine, 67 (3). pp. 222-231. ISSN 1532-0820. https://resolver.caltech.edu/CaltechAUTHORS:20170705-102920475

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Abstract

Animal models are vital in understanding the transmission and pathogenesis of infectious organisms and the host immune response to infection. In addition, animal models are essential in vaccine and therapeutic drug development and testing. Prior to selecting an animal model to use when studying an infectious agent, the scientific team must determine that sufficient in vitro and ex vivo data are available to justify performing research in an animal model, that ethical considerations are addressed, and that the data generated from animal work will add useful information to the body of scientific knowledge. Once it is established that an animal should be used, the questions become 'Which animal model is most suitable?' and 'Which experimental design issues should be considered?' The answers to these questions take into account numerous factors, including scientific, practical, welfare, and regulatory considerations, which are the focus of this article.


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http://www.ingentaconnect.com/contentone/aalas/cm/2017/00000067/00000003/art00005PublisherArticle
Additional Information:© 2017 American Association for Laboratory Animal Science. Publication date: June 1, 2017.
Issue or Number:3
Record Number:CaltechAUTHORS:20170705-102920475
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20170705-102920475
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:78761
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:06 Jul 2017 21:43
Last Modified:03 Oct 2019 18:11

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